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This research intends to analyze how a 12-week adjustment in lifestyle influences inflammatory cytokines and oxidative stress indicators in overweight individuals diagnosed with type 2 diabetes and moderate CKD
: 60 patients, mostly sedentary, aged 36-58 years, were diagnosed with stages 3 and 4 chronic kidney disease (eGFR 25 to 60 ml/min/1.73 m²) with concomitant type 2 diabetes and indicated body mass indexes (BMI) between 30 to 35 kg/m². The subjects were randomly assigned to two unique groups: Intervention group (Group A): Participants completed supervised aerobic treadmill exercises while sticking to a calorie-limited diet (1200 kcal/day) throughout a 12-week period. Control group (Group B): Participants received standard nephrology care without any alterations in lifestyle. In the initial phases, there was a detailed analysis of biomarkers which was later confirmed in a review conducted at the 12-week mark focusing on TNF-α, IL-6, sCRP, CD, MDA, GSH, GPx, and SOD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| (Group A) | Experimental | Participants completed supervised aerobic treadmill exercises while sticking to a calorie-limited diet (1200 kcal/day) throughout a 12-week period. |
|
| group (B) | No Intervention | Participants received standard nephrology care without any alterations in lifestyle. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| aerobic treadmill exercises | Other | diet (1200 kcal/day) |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| MDA | malondialdehyde | at baseline and after 12 WEEKS |
| GSH | Glutathione | at baseline and after 12 WEEKS |
| GPx | Glutathione peroxidase | at baseline and after 12 WEEKS |
| SOD | Superoxide dismutase | at baseline and after 12 WEEKS |
| IL-6 | Interleukin-6 | at baseline and after 12 WEEKS |
| TNF-α | tumor necrosis factor alpha | at baseline and after 12 WEEKS |
| CRP | C-reactive protein | at baseline and after 12 WEEKS |
| Measure | Description | Time Frame |
|---|---|---|
| BMI | Body mass index | at baseline and after 12 WEEKS |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mona Mohamed Abdelkhalek, assistance professor | Contact | 00201024056108 | 3m.sons@gmail.com | |
| Mona Mohamed Abdelkhalek, assistance professor | Contact | 00201024056108 | mona.abdelkhalek@buc.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Mona Mohamed Abdelkhalek | Badr University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mona Mohamed Abdelkhalek | Recruiting | Cairo | Egypt |
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| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D003920 | Diabetes Mellitus |
| D015431 | Weight Loss |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D001836 | Body Weight Changes |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |