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| ID | Type | Description | Link |
|---|---|---|---|
| MYSELF | Other Identifier | MYSELF |
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COMPARISON OF OUTCOME OF HYPOXIC ISCHEMIC ENCEPHALOPATHY MANAGED WITH COMBINATION OF MAGNESIUM SULPHATE AND MELATONIN VERSUS MAGNESIUM SULPHATE ALONE Participants of group A will have 3 doses of MgSO4 infusion at rate of 250mg/kg per day intravenous over 1hour on day 0,1,2 Participants of group B will have 5 doses of Melatonin 10mg/kg for 5days along with MgSO4. They will undergo reassessment of arterial PH and serum LDH after completion of therapy. They will be followed for length of hospital stay and time until feed is initiated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| melatonin along with Mgso4 infusion | Experimental | five doses of melatonin (10mg/kg daily enteral for 5days) along with Three doses of MgSO4 infusion at the rate of 250mg/kg per day intravenous over 1 hour on days 0, 1, and 2 |
|
| Mgso4 alone | Active Comparator | Three doses of MgSO4 infusion at the rate of 250mg/kg per day intravenous over 1 hour on days 0, 1, and 2 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MgSO4 (seizure prevention) | Drug | Three doses of MgSO4 infusion at the rate of 250mg/kg per day intravenous over 1 hour on days 0, 1, and 2 |
|
| Measure | Description | Time Frame |
|---|---|---|
| 1.Change in PH 2.Serum LDH(U/L) | change in arterial PH,SERUM LDH | 5 DAYS |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| dr akasha rehman rehman, MD Pedatrics | Contact | 923041867246 | akasharehman55@gmail.com | |
| alia ahmed, FCPS,MRCPCH,FRCPCH | Contact | 923344081996 | alia_ahmad99@yahoo.com |
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I do not plan to share raw participant data
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| Melatonin , Mgso4 | Drug | Five doses of melatonin along with three doses of MgSO4 infusion at the rate of 250mg/kg per day intravenous over 1 hour on days 0, 1, and 2 |
|
| ID | Term |
|---|---|
| D008550 | Melatonin |
| D008278 | Magnesium Sulfate |
| ID | Term |
|---|---|
| D014363 | Tryptamines |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D017616 | Magnesium Compounds |
| D007287 | Inorganic Chemicals |
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |
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