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The incidence of cerebral vasospasm after aneurysm subarachnoid hemorrhage (aSAH) is as high as 70%; cerebral vasospasm(CVS) is closely related to delayed cerebral ischemia (DCI), which is one of the important reasons for poor outcomes in patients with aSAH.
In recent years, it has been reported that stellate ganglion block(SGB) can effectively alleviate cerebral vasospasm(CVS), reduce cerebral blood flow velocity and increase cerebral perfusion in patients with aneurysm subarachnoid hemorrhage(aSAH)。However, whether the alleviation of CVS after SGB is beneficial to the long-term neurological prognosis has not been confirmed Therefore, a prospective randomized controlled study is needed to further explore the role of SGB block in improving the outcomes of patients with aSAH.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention group | Experimental | In addition to routine anesthesia management and surgical operations, an ultrasound-guided stellate ganglion block was performed once prior to the initiation of surgery, and then receive standard care after operation. Related statistical indicators were collected prospectively. |
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| Blank control group | No Intervention | In this study, a blank control was used. Routine anesthesia management and surgical operation were used without any special interventions, and then receive standard care after operation. Only relevant statistical indicators were collected prospectively. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intervention group | Procedure | Prior to the initiation of surgery, a single ultrasound-guided stellate ganglion block was performed on the ipsilateral side of the lesion.The dose and concentration of local anesthesia: 0.5% ropivacaine 5-10ml. Criteria for successful block: the patient developed Horner's syndrome, characterized by miosis, ptosis, eyeball caved in, nasal congestion, conjunctival congestion, reddish face and no sweat on the face |
| Measure | Description | Time Frame |
|---|---|---|
| The modified Rankin Scale (mRS) scores at 90 days | The modified Rankin Scale (mRS) is used to evaluate the primary outcome. The scale of mRS is 0 to 6. The best neurological outcome is the mRS with 0, indicating no any symptom left. mRS of 6 is the worst, indicating death. mRS will be evaluated by outcomes assessor who is blinded to the grouping. | 90 days postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of delayed cerebral ischemia (DCI) during hospitalization | At discharge, an average of 2 weeks | |
| All cause mortality during 90 days after onset | 90 days postoperatively | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ruquan Han, M.D., Ph.D | Contact | 8610-59976660 | ruquan.han@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Ruquan Han, M.D., Ph.D | Beijing Tiantan Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Tiantan Hospital, Capital Medical University | Beijing | Beijing Municipality | 100070 | China |
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| ID | Term |
|---|---|
| D013345 | Subarachnoid Hemorrhage |
| ID | Term |
|---|---|
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Length of stay in the intensive care unit and hosipital |
| At discharge, an average of two weeks |
| Adverse events during hospitalization | Myocardial infarction, cardiac arrest, pulmonary embolism, infection, SGB related complications, etc | At discharge, an average of 2 weeks |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |