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Protocol details were entered incorrectly; study withdrawn before any enrollment.
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This study aims to evaluate whether structural and functional parameters of the left atrium and left ventricle, measured by cardiac computed tomography angiography (CCTA), can predict clinical outcomes after radiofrequency ablation in patients with atrial fibrillation (AF). Atrial fibrillation is a common heart rhythm disorder, and while catheter ablation is an effective treatment, some patients experience recurrence. Current predictive tools have limitations. This prospective observational study will enroll patients with AF scheduled for first-time radiofrequency ablation. All participants will undergo CCTA before the ablation procedure to assess left atrial and left ventricular volumes, ejection fraction, and strain parameters. After ablation, patients will be followed for 12 months to monitor recurrence of atrial arrhythmias. The primary outcome is the recurrence of atrial fibrillation or atrial tachycardia lasting more than 30 seconds after a 3-month blanking period. The study will determine whether CCTA-derived parameters improve risk stratification for post-ablation recurrence. Findings may help identify patients who are more likely to benefit from ablation or who may need additional therapy.
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| Measure | Description | Time Frame |
|---|---|---|
| Recurrence of atrial arrhythmia after ablation | Recurrence of atrial fibrillation, atrial flutter, or atrial tachycardia lasting 30 seconds or longer, documented by electrocardiogram (ECG) or Holter monitoring, after a 3-month blanking period following radiofrequency ablation. | 12 months after ablation (following the initial 3-month blanking period) |
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Inclusion Criteria:
Exclusion Criteria:
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Consecutive patients with paroxysmal or persistent atrial fibrillation referred for first-time radiofrequency catheter ablation at Nanjing First Hospital.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nanjing First Hospital, Nanjing Medical University, 68 Changle road, Qinhuai District | Nanjing | Jiangsu | 210006 | China |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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