The purpose of this study is to find out whether a urine test can detect colorectal cancer (CRC) and precancerous polyps in participants living in Ghana, Tanzania, and South Africa.

Inclusion Criteria:

• Patient presents with one of the following:

  • Patients with symptoms of CRC (such as rectal bleeding for a week) -OR-

  • Patients who present for a screening colonoscopy -OR-

  • Has received one of the following within 3 weeks of the planned urine collection

    • Patients with a pathologic diagnosis of CRC either by colonoscopy or resection specimens -OR-
    • Patients with colonoscopy demonstrating adenomatous polyps -OR-
    • Patients with colonoscopy demonstrating no colon or premalignant or malignant pathology

• Age ≥ 18

• Willingness to participate in the study

Data and samples will be collected from 3 sites in Africa: Korle Bu Teaching Hospital/University of Ghana Medical School in Ghana; Kilimanjaro Christian Medical Centre in Tanzania and Wits Donald Gordon Medical Centre, Wits Donald Gordon Medical Research Institute in South Africa. Consent will occur at these sites.

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made following one year after publication and for up to 36 months later. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.