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This study evaluates corneal epithelial thickness using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. It aims to assess the relationship between epithelial thickness patterns and different types of refractive errors.
Refractive errors are among the most common ocular conditions affecting visual acuity. Corneal epithelial thickness has been suggested to play a role in the optical properties of the eye and may vary among different refractive states. This observational study aims to evaluate corneal epithelial thickness mapping using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. Patients will be assessed and categorized according to their refractive status, and epithelial thickness measurements will be obtained and analyzed. The study seeks to investigate potential correlations between epithelial thickness distribution and different types of refractive errors to enhance understanding of corneal biomechanics in refractive conditions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All Participants | All participants diagnosed with refractive errors (myopia, hyperopia, astigmatism) and emmetropia will be included in the study. All subjects will undergo anterior segment optical coherence tomography (AS-OCT) for corneal epithelial thickness mapping. Participants will then be analyzed according to their refractive status. |
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| Measure | Description | Time Frame |
|---|---|---|
| Measurement of corneal epithelial thickness using AS-OCT | Corneal epithelial thickness will be measured using anterior segment optical coherence tomography (AS-OCT). Measurements will include central and regional epithelial thickness values in microns in patients with different refractive errors. | At baseline during a single study visit when participants undergo AS-OCT examination. |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of epithelial thickness between myopic and hyperopic eyes | Corneal epithelial thickness will be compared between myopic and hyperopic eyes using AS-OCT measurements. | At baseline (single visit) |
| Comparison of epithelial thickness in eyes with and without astigmatism |
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Inclusion Criteria:
Exclusion Criteria:
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Adult participants (≥18 years) with refractive errors, including myopia, hyperopia, and astigmatism, as well as emmetropic subjects, recruited from the Ophthalmology Department and undergoing anterior segment optical coherence tomography (AS-OCT) examination.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Merna romany loza, MBBCh, Ophthalmology Resident | Contact | 01275800331 | mernaromany54@yahoo.com | |
| Engy Mohamed Mostafa, Professor | Contact | 01005643587 | Engymostafa@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Engy Mohamed Mostafa, Professor | Department of Ophthalmology, Faculty of Medicine, Sohag University | Principal Investigator |
| Amin Abu-Ali Hassan, Assistant Professor | Department of Ophthalmology, Faculty of Medicine, Sohag University |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag University Hospital | Sohag | Sohag Governorate | 82524 | Egypt |
Individual participant data will not be shared.
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| ID | Term |
|---|---|
| D009216 | Myopia |
| D006956 | Hyperopia |
| D001251 | Astigmatism |
| D012030 | Refractive Errors |
| D003316 | Corneal Diseases |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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Corneal epithelial thickness will be evaluated and compared between eyes with astigmatism and those without astigmatism using AS-OCT. |
| At baseline (single visit) |
| Corneal epithelial thickness asymmetry across corneal regions and inter-eye comparison | Epithelial thickness will be assessed across different corneal regions and compared between both eyes to evaluate inter-eye asymmetry. | At baseline (single visit) |
| Comparison of epithelial thickness in low and high refractive errors | Corneal epithelial thickness profiles will be compared between low and high degrees of myopia and hyperopia using AS-OCT measurements. | At baseline (single visit) |
| Yasmeen Gamal Abd-El latif, Lecturer | Department of Ophthalmology, Faculty of Medicine, Sohag University | Study Director |