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This project examines whether consuming a high-protein or high-carbohydrate beverage before exercise in the heat impacts metabolism and heat balance during exercise, with the following research questions:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High Protein | Experimental | A 22-oz high-protein, low-carbohydrate shake (chocolate flavor), given 60-90 minutes before exercise. |
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| High Carbohydrate | Active Comparator | A 22-oz, high-carbohydrate, low-protein & fat shake (chocolate flavor), given 60-90 minutes before exercise |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Protein shake | Dietary Supplement | 22 oz of a beverage containing 320 kilocalories (60g protein, 6g fat, 8g carbohydrate). |
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| Measure | Description | Time Frame |
|---|---|---|
| Metabolic Heat Production | Heat production measured during exercise at 6 watts/kg, calculated based on oxygen consumption and carbon dioxide production during exercise (indirect calorimetry) | Measured during 60 minutes of steady state exercise in 36C, 40% humidity |
| Measure | Description | Time Frame |
|---|---|---|
| Core Temperature | Internal temperature change during exercise | Measured at rest and following 60 minutes of exercise in a warm (36C, 40% humidity) environment |
| Urinary NGAL (ng/mL) | Measured after exercise in high-protein and high-carbohydrate trials, NGAL (neutrophil-gelatinase associated lipocalin; a marker of acute kidney injury) will be measured in urine samples in each trial to assess kidney function. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Brett R Ely, PhD | Contact | 401-865-2632 | bely@providence.edu | |
| Margaret Morrissey-Basler, PhD | Contact | 401-865-1209 | mmorri17@providence.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| ICF | No | No | Yes | Informed Consent Form | May 20, 2026 | Jun 10, 2026 | ICF_000.pdf |
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| ID | Term |
|---|---|
| D018882 | Heat Stress Disorders |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D001519 | Behavior |
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Double-blind crossover design
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| Carbohydrate shake | Dietary Supplement | 22oz of a carbohydrate drink containing 320 kilocalories (75g carbohydrate, 3g protein, <1g fat) |
|
| Following 60 minutes of exercise in a warm environment (36C, 40% relative humidity) |
| Urine Specific Gravity (USG) | Measured in urine samples provided before and after exercise, USG will be used as a marker of urine concentration and hydration status with each intervention. | Measured before and after 60 minutes of exercise in a warm (36C, 40%RH) environment. |
| Proteinuria | Measured after exercise in high-protein and high-carbohydrate trials, total protein content will be measured in urine samples in each trial to assess kidney function. | Following 60 minutes of exercise in a warm environment (36C, 40% relative humidity) |