Clinical Trial to Evaluate the Efficacy and Safety of Conjuran® After First and Second Cycle (Repeat) Administration in Patients With Knee Osteoarthritis

A Multicenter, Randomized, Double-Blind, Active-Controlled, Non-Inferiority Clinical Trial to Evaluate the Efficacy and Safety of Intra-Articular Conjuran® After First and Second Cycle (Repeat) Administration in Patients With Knee Osteoarthritis

This clinical trial aims to evaluate and compare the efficacy and safety of Conjuran® and Hyruan in patients with knee osteoarthritis following first and second cycle (repeat) administration.

Inclusion Criteria:

• Age ≥40 years
• Knee osteoarthritis diagnosed according to ACR criteria
• KL grade I-III
• Weight-bearing pain VAS ≥40 mm
• Written informed consent

Exclusion Criteria:

• Inflammatory or secondary arthritis
• Recent treatment in the target knee
• Significant uncontrolled medical conditions
• Hypersensitivity to study device components
• Pregnancy or breastfeeding
• Participation in another clinical trial