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The goal of this clinical trial is to learn whether adjunctive electrolytic surface decontamination can improve the outcomes of surgical treatment of peri-implantitis. The main questions it aims to answer are:
Researchers will compare conventional surgical treatment plus electrolytic surface decontamination with conventional surgical treatment alone.
Participants will:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conventional Surgical Treatment Alone | Active Comparator | Participants assigned to this arm will receive conventional surgical treatment for peri-implantitis. Treatment will include flap elevation, mechanical implant surface decontamination using a titanium brush, and hydrogen peroxide application according to the study protocol. |
|
| Conventional Surgical Treatment Plus Electrolytic Surface Decontamination | Experimental | Participants assigned to this arm will receive conventional surgical treatment for peri-implantitis, including flap elevation, mechanical implant surface decontamination using a titanium brush. In addition, electrolytic surface decontamination will be performed according to the study protocol. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Electrolytic Surface Decontamination | Procedure | Electrolytic implant surface decontamination performed using the GalvoSurge system as an adjunct to conventional surgical treatment. The procedure is intended to remove biofilm and contaminants from the implant surface through an electrolytic cleaning process. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Probing Pocket Depth (PPD) | Change in peri-implant probing pocket depth (PPD) measured in millimeters at treated implant sites. The difference between baseline and 24-month follow-up measurements will be evaluated. | 24 Months |
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Inclusion Criteria:
Adults aged 18 years or older Diagnosis of peri-implantitis requiring surgical treatment Presence of at least one dental implant diagnosed with peri-implantitis Ability and willingness to attend follow-up visits Provision of written informed consent
Exclusion Criteria:
Pregnancy or lactation Uncontrolled systemic diseases that may affect healing Immunosuppressive therapy History of head and neck radiotherapy Current use of medications known to affect bone metabolism Inability to comply with the study protocol or follow-up schedule Previous surgical treatment of peri-implantitis at the study implant site
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Volkan Arısan, Professor | Contact | +90 2124400000 | varisan@istanbul.edu.tr |
| Name | Affiliation | Role |
|---|---|---|
| Volkan Arısan, Professor | Istanbul University Faculty of Dentistry | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istanbul University Faculty of Dentistry | Istanbul | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41788049 | Result | Puisys A, Akhondi S, Vindasiute-Narbute E, Zvirblis T, Gallucci GO, Pedrinaci I. Peri-Implant Reconstruction With Autogenous Bone and Electrolytic Therapy: A Randomized Controlled Clinical Trial. Clin Implant Dent Relat Res. 2026 Apr;28(2):e70123. doi: 10.1111/cid.70123. | |
| 42047219 | Result | Monje A, Reffassi MS, Valles C, Gourdache I, Kumar P, Nart J. Understanding peri-implantitis occurrence and recurrence following treatment: A patient-centered study. J Periodontol. 2026 Apr 28. doi: 10.1002/jper.70133. Online ahead of print. |
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|
| Conventional Surgical Treatment | Procedure | Conventional surgical treatment of peri-implantitis consisting of flap elevation, mechanical implant surface decontamination using a titanium brush, and hydrogen peroxide application according to the study protocol. |
|
| Istanbul University Faculty of Dentistry | Istanbul | Turkey (Türkiye) |
|
| 40464209 | Result | Arisan V, Saglanmak A, Anil A, Arici SV, Sculean A. Photodynamic Therapy as an Adjunct to Resective and Regenerative Surgical Treatment of Peri-Implantitis: A Prospective Cohort of 72 Patients Followed for 18 Months. Oral Health Prev Dent. 2025 Jun 3;23:305-314. doi: 10.3290/j.ohpd.c_2078. |
| ID | Term |
|---|---|
| D057873 | Peri-Implantitis |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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