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| ID | Type | Description | Link |
|---|---|---|---|
| L252086 | Other Grant/Funding Number | Beijing Natural Science Foundation | |
| KS2025225 | Other Identifier | Ethics Committee of Beijing Anzhen Hospital, Capital Medical University |
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This prospective cohort study aims to investigate postoperative cognitive dysfunction in patients undergoing off-pump coronary artery bypass grafting. Eligible patients will be enrolled before surgery and followed after surgery. Cognitive function will be assessed using the Montreal Cognitive Assessment before surgery and at predefined postoperative time points. Perioperative clinical information, including preoperative assessment data, intraoperative monitoring parameters, and postoperative clinical data, will be collected. The study will evaluate the occurrence of postoperative cognitive dysfunction and explore its association with perioperative factors.
This is a prospective observational cohort study of patients undergoing off-pump coronary artery bypass grafting. The study aims to investigate postoperative cognitive dysfunction and its association with perioperative clinical factors. Eligible patients will be enrolled before surgery and followed after surgery according to the study protocol.
Baseline information will be collected before surgery, including demographic characteristics, medical history, comorbidities, laboratory test results, and preoperative cognitive assessment. Intraoperative and postoperative data will also be collected, including anesthesia-related variables, surgical information, hemodynamic and monitoring parameters, postoperative clinical status, and relevant complications.
Cognitive function will be assessed before surgery and at predefined postoperative time points using standardized cognitive assessment tools, such as the Montreal Cognitive Assessment. Postoperative cognitive dysfunction will be determined according to the predefined criteria based on changes in cognitive assessment results from baseline to postoperative follow-up.
The study will describe the incidence of postoperative cognitive dysfunction after off-pump coronary artery bypass grafting and evaluate the association between perioperative factors and postoperative cognitive outcomes. The results may help improve understanding of postoperative cognitive dysfunction in this surgical population and provide evidence for perioperative risk assessment and clinical management.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Off-Pump Coronary Artery Bypass Grafting Cohort | Patients undergoing off-pump coronary artery bypass grafting who will receive preoperative cognitive assessment and postoperative follow-up for postoperative cognitive dysfunction. Perioperative clinical information, including preoperative assessment data, intraoperative monitoring parameters, and postoperative clinical data, will be collected. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Off-Pump Coronary Artery Bypass Grafting | Procedure | Off-pump coronary artery bypass grafting is performed as part of routine clinical care for patients with coronary artery disease. The study protocol does not assign participants to this procedure or to any additional intervention. This observational study will collect perioperative clinical data and follow patients after surgery to assess postoperative cognitive dysfunction. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Postoperative Cognitive Dysfunction | Postoperative cognitive dysfunction will be evaluated by comparing postoperative Montreal Cognitive Assessment scores with preoperative baseline scores. Preoperative cognitive function will be assessed using the Montreal Cognitive Assessment 1 day after hospital admission. Postoperative cognitive function will be assessed using the Montreal Cognitive Assessment on postoperative day 7 or, if the patient is discharged before postoperative day 7, 1 day before hospital discharge. Postoperative cognitive dysfunction is defined as a decline in the postoperative Montreal Cognitive Assessment score of at least 1 standard deviation compared with the preoperative baseline score. | Postoperative Day 7, or 1 Day Before Hospital Discharge if Discharged Before Postoperative Day 7 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Montreal Cognitive Assessment Score | The change in Montreal Cognitive Assessment score will be calculated by comparing the postoperative score with the preoperative baseline score. Preoperative cognitive function will be assessed 1 day after hospital admission, and postoperative cognitive function will be assessed on postoperative day 7 or, if the patient is discharged before postoperative day 7, 1 day before hospital discharge. |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients scheduled to undergo elective off-pump coronary artery bypass grafting at Beijing Anzhen Hospital, Capital Medical University, will be prospectively enrolled. Eligible patients must be able to complete preoperative cognitive assessments and provide informed consent. Patients will be followed after surgery to evaluate postoperative cognitive dysfunction.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wenjun Liu, PhD | Contact | +86 13811258408 | lwjchina@163.com | |
| Xuefei Jia, phD | Contact | +86 13121380377 | jiaxuefei0320@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Wenjun Liu, PhD | Beijing Anzhen Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Anzhen Hospital, Capital Medical University | Beijing | Beijing Municipality | 100029 | China |
Individual participant data will not be shared due to privacy, ethical, and institutional data protection considerations.
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| ID | Term |
|---|---|
| D000079690 | Postoperative Cognitive Complications |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D060825 | Cognitive Dysfunction |
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| Postoperative Day 7, or 1 Day Before Hospital Discharge if Discharged Before Postoperative Day 7 |
| Length of Intensive Care Unit Stay | The length of intensive care unit stay will be recorded as the number of days from admission to the intensive care unit after surgery to discharge from the intensive care unit. | through ICU discharge, an average of 3 days |
| Length of Postoperative Hospital Stay | The length of postoperative hospital stay will be recorded as the number of days from the date of surgery to the date of hospital discharge. | through hospital discharge, an average of 7 days |
| Incidence of Postoperative Complications | Postoperative complications during hospitalization will be recorded, including cardiovascular, respiratory, neurological, renal, infectious, thromboembolic, and wound-related complications. | through hospital discharge, an average of 7 days |
| Duration of Postoperative Mechanical Ventilation | The duration of postoperative mechanical ventilation will be recorded as the time from postoperative intensive care unit admission to successful discontinuation of mechanical ventilation. | through ICU stay, an average of 3 days |
| Incidence of Postoperative Nausea and Vomiting | Postoperative nausea and vomiting during the postoperative hospitalization period will be recorded based on medical records. | through hospital discharge, an average of 7 days |
| Incidence of In-Hospital Mortality | In-hospital mortality will be recorded as death from any cause during the postoperative hospitalization period. | through hospital discharge, an average of 7 days |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |