Participants in this group utilize the personalized digital platform to record adverse events as Patient-Reported Outcomes (PROs). Additionally, they receive short textual personalized educational and supportive material online.

Their standard clinical treatment and monitoring continue unaffected.

Participants in this group utilize the personalized digital platform to record adverse events as Patient-Reported Outcomes (PROs). They only receive an acknowledgement of their submission.

Their standard clinical treatment and monitoring continue unaffected.

Personalized educational and supportive material, based on each patients' adverse events reported as PROs, delivered via the online platform.

Patient-Reported Outcomes (PROs) consisting of treatment related side-effects that patients themselves report on the online platform. The reported side-effects will be evaluated throughout the entire duration of the study.

17 side-effects will be captured (each measured as either present or absent) throughout the study:

1. Ocular toxicity
2. Fatigue
3. Diarrhea
4. Constipation
5. Neuropathy
6. Dermatological toxicity
7. Dyspnoea
8. Insomnia
9. Nausea
10. Vomiting
11. Dry mouth
12. Nail problems
13. Memory problems
14. Hypertension
15. Lower extremity oedema
16. Sexual dysfunction
17. Bone pain

Only data from patients who report at least 2 times will be eligible for outcome analysis.

The following calculation and evaluation will be conducted:

For each of the two Arms, the percentage of patients who at the final side-effect data collection reported fewer than 50% of the specific side-effects they had reported at previous side-effect data collection timepoints.

Progression-free survival: Laboratory-confirmed disease progression or death, measured from study entry