Randomized In-Vivo Comparison of 3D-Printed and Thermoformed Clear Aligners: A Multi-Subject, Time-Dependent Analysis of Adaptation and Trueness

3D-Printed and Thermoformed Clear Aligners: Analysis of Adaptation and Trueness.

This prospective clinical study aims to evaluate and compare the in vivo adaptation and trueness of clear aligners fabricated using thermoforming and direct three-dimensional (3D) printing technologies.

Inclusion Criteria

• Healthy adult volunteers aged 18 years or older.
• Good general and oral health.
• Dentition adequate to support passive upper clear aligner wear, as determined by the investigator.
• Willing and able to attend all study visits over the 4-6 month study period.
• Willing and able to comply with aligner wear and all study procedures.
• Able to provide written informed consent and HIPAA authorization.

Exclusion Criteria

• Active dental or periodontal disease, or any oral condition that could interfere with study procedures.
• Need for active orthodontic treatment or other dental procedures during the study period.
• Poor oral hygiene or failure to follow study instructions at the screening visit.
• Medical or systemic conditions, or use of medications, that could compromise participation or study outcomes.
• Concurrent participation in another interventional research study.
• Pregnancy or planned pregnancy during the study period (if applicable).