Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain

Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain

To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.

Inclusion Criteria:

• Diagnosis of chronic pain (generally pain duration of at least 3-6 months) localized to an anatomical region appropriate for cryoneurolysis as determined by the treating physician.
• Planned cryoneurolysis procedure as part of standard clinical care.
• Ability to provide written informed consent.
• Ability and willingness to complete baseline and follow-up questionnaires.

Exclusion Criteria:

• Cryoneurolysis performed as part of a separate investigational trial in which data sharing is not permitted.
• Active infection or other clinical contraindication to the procedure as determined by the treating clinician.
• Life expectancy of less than 12 months in the judgment of the treating clinician.
• Any condition that, in the investigator's opinion, would interfere with study participation or completion of follow-up, such as severe psychiatric instability or active substance use that precludes reliable follow-up