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Demonstration of soft tissue hypoxia on MRI using external compression and muscle contraction.
Participant will undergo a single MRI examination. Standard orthopedic Sarmiento brace/ shell applied to participant's arm. Inside the brace will be a standard blood pressure cuff with a standard brace soft foam attached; blood pressure cuff will be partially inflated. Participant will also be asked to lift MRI compatible 10 lb. weight. Muscle oxygenation will be actively measured using MRI. No medications are being given, and no invasive devices are being used.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MRI | Experimental | Participant will undergo a single MRI examination of arm with no contrast. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Compression and Contraction | Other | Standard orthopedic Sarmiento brace/ shell applied to participant's arm. Inside the brace will be a standard blood pressure cuff with a soft foam attached. Pressure will be applied intermittently with blood pressure cuff. Participant will also be asked to lift MRI compatible 10 lb. weight. |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle oxygen level | Using functional MRI to evaluate effect of muscle compression on muscle oxygen. Demonstrating statistically significant change in muscle oxygen in tissues with application of tissue compression and muscle contraction compared to the same, non-compressed tissues with only muscle contraction | Day 1, during procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Deep tissue oxygen level | Using functional MRI to evaluate the effect of muscle compression and contraction on deep tissue oxygen. Demonstrate statistically greater decreased tissue oxygenation in the deep soft tissues compared to the superficial tissues below the deforming element, during application of tissue compression, during muscle contraction as well during application of tissue compression and muscle contraction. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yudell Edelstein, MD | Contact | 212-244-8864 | yudell.edelstein@mountsinai.org |
| Name | Affiliation | Role |
|---|---|---|
| Yudell Edelstein, MD | Icahn School of Medicine at Mount Sinai | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mount Sinai Hess Center | Recruiting | New York | New York | 10029 | United States |
There is no staff available to manage data sharing
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| Day 1, during procedure |