Effect of Medication Adherence-Based Digital Intervention on Fatigue Severity, Weight, and Thyroid Hormone Regulation

Effect of Medication Adherence-Based Digital Intervention on Fatigue Severity, Weight, and Thyroid Hormone Regulation in Patients With Hypothyroidism: A Randomized Controlled Trial

1. To evaluate the effect of a medication adherence-based digital intervention on fatigue severity in patients with hypothyroidism.
2. To assess the effect of a medication adherence-based digital intervention on weight in patients with hypothyroidism.
3. To investigate the effect of a medication adherence-based digital intervention on thyroid hormone regulation in patients with hypothyroidism.

Inclusion Criteria:

• Adults (≥18 years) with primary hypothyroidism.
• On stable levothyroxine therapy for at least 3 months.
• Able to read, understand study instructions
• capable of using basic mobile applications
• poor medication adherence, clinically significant fatigue, documented weight fluctuations and abnormal thyroid hormone

Exclusion Criteria:

• Secondary hypothyroidism or recent thyroidectomy/radioactive iodine therapy.
• Pregnancy or breastfeeding woman.
• Severe psychiatric disorders or cognitive impairment
• significant visual or hearing deficits
• Serious comorbidities affecting medication adherence (e.g., chronic disease, renal, or hepatic disease).
• take dietary supplements or medications that interfere with levothyroxine absorption.