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This study includes patients diagnosed with proximal gastric cancer (Siewert type II/III, cT1-3N0-1M0) across six tertiary hospitals, who underwent either double-tract reconstruction (DTR) or tubular gastric anastomosis (TGA). Participants were divided into two groups based on the surgical procedure. We conducted a comparative analysis of postoperative outcomes by evaluating electronic medical records, postoperative gastroscopy, 24-hour esophageal pH monitoring, and relevant rating scales.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DTR Group | Experimental | Patients in this group underwent radical proximal gastrectomy with double-tract reconstruction. |
|
| TGA Group | No Intervention | Patients in this group underwent radical proximal gastrectomy with tubular gastric anastomosis. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Double-tract reconstruction | Procedure | Patients underwent double-tract reconstruction after radical proximal gastrectomy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of postoperative reflux esophagitis | The diagnosis of reflux esophagitis was based on symptoms, endoscopic findings, and 24-hour esophageal pH monitoring. | 6 month after surgery |
| Severity of reflux esophagitis | According to the diagnostic and grading criteria for reflux esophagitis, patients were classified into four categories: no reflux esophagitis, mild (LA-A/B), moderate (LA-C), and severe (LA-D). | 6 month after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative nutritional recovery | The body weight change rate at different postoperative time points compared with preoperative levels, along with albumin, prealbumin, and hemoglobin levels, were comprehensively considered in the assessment of postoperative nutritional status. | 1 year after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hui Qu, Doctor of Medicine | Contact | +8618560085120 | doctorquhui@email.sdu.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Qilu Hospital of Shandong University | Recruiting | Jinan | Shandong | 250012 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41399049 | Result | Kim MC, Jung MR, Noh JJ, Kang S, Chung JH, Park JH, Kim TH, Park JK, Kim Y, Seo SH, Kim SE, Kwon OK, Park JY, Park KB, Hwang SH, Lee SH, Lee YJ, Jeong SH, Jeon TY, Kim DH, Choi CI, Yoon KY, Seo KW, Kim KH, Oh SH, Kim KH. Current status of treatment for esophagojejunostomy leakage after total gastrectomy in patients with gastric cancer: a multicenter retrospective study in Korea. J Minim Invasive Surg. 2025 Dec 15;28(4):184-192. doi: 10.7602/jmis.2025.28.4.184. | |
| 41196468 |
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| ID | Term |
|---|---|
| D013274 | Stomach Neoplasms |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| Result |
| Xin C, Wang Z, Zheng Z, Lu S, Wei X, Zhang J, Yin J, Zhang Z. Comparison on the reflux and nutritional status of different reconstruction methods after laparoscopic proximal gastrectomy: a systematic review and network meta-analysis. Updates Surg. 2026 Apr;78(2):575-588. doi: 10.1007/s13304-025-02324-9. Epub 2025 Nov 6. |
| 32060757 | Result | Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2018 (5th edition). Gastric Cancer. 2021 Jan;24(1):1-21. doi: 10.1007/s10120-020-01042-y. Epub 2020 Feb 14. No abstract available. |
| 40676300 | Result | Zhou J, Li R, Cheng Y, Zhao S, Wang J, Fu Y, Tian Z, Wang L, Wang W, Ren J, Wang D. Comparison of channel esophagogastrostomy and double tract reconstruction after laparoscopic-assisted proximal gastrectomy: a propensity score-matched analysis. Surg Endosc. 2025 Sep;39(9):5722-5732. doi: 10.1007/s00464-025-11978-w. Epub 2025 Jul 17. |
| 39580964 | Result | Tian Z, Cheng Y, Wang Y, Ren J, Wang S, Wang D. A 3-Arm case-matched analysis of anti-reflux reconstruction methods after laparoscopic proximal gastrectomy - Single tract jejunal interposition vs double tract reconstruction vs tube-like stomach reconstruction. Eur J Surg Oncol. 2025 Feb;51(2):109482. doi: 10.1016/j.ejso.2024.109482. Epub 2024 Nov 19. |
| 40960020 | Result | Liu Y, Yan M, Lin Z, Wei S, Li Y, Lin Z, Chen X. Short- and Mid-Term Outcomes of Proximal Gastrectomy With Double-Tract Reconstruction Versus Total Gastrectomy in Early-Stage Proximal Gastric Cancer. Cancer Med. 2025 Sep;14(18):e71258. doi: 10.1002/cam4.71258. |
| 40898955 | Result | Chen CY, Kung CY, Shyr BS, Huang KH, Fang WL, Lin SC, Li AF, Lo SS, Wu CW, Lan YT. Comparison of operative outcomes between proximal and total gastrectomy for proximal gastric cancer. J Chin Med Assoc. 2025 Oct 1;88(10):800-806. doi: 10.1097/JCMA.0000000000001287. Epub 2025 Sep 3. |
| D004066 |
| Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |