Triggered Imaging in Glioblastoma Based on Clinical Outcome Evaluation Compared to Routine: a Feasibility Study

Triggered Imaging in Glioblastoma Based on Clinical Outcome Evaluation Compared to Routine: a Feasibility Study

This is a feasibility randomized controlled trial comparing triggered imaging based on patient symptom self-reporting and performance-based measures with the existing imaging schedule.

Patients in intervention arm will be invited to complete weekly online symptom questionnaires. Responses will be evaluated and given a score, with higher scores reflecting 'red flag' symptoms or symptoms of a severity which meet pre-defined thresholds.

Inclusion Criteria:

i. Newly diagnosed glioblastoma (WHO grade IV) ii. Planned to undergo the Stupp treatment regimen iii. Aged 18-70 iv. To be treated at KCH and GSTT v. No MRI contraindications vi. Patients with internet access and an e-mail account

Exclusion Criteria:

i. Uncertainty of diagnosis ii. Deviation from the standard Stupp regimen iii. Patients participating in another interventional study iv. Unable to read and comprehend English language text v. Lack capacity at point of consent vi. WHO Performance status > 3 (Karnofsky score < 30)