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| ID | Type | Description | Link |
|---|---|---|---|
| Ethics Approval 9/XVI-2022 | Other Identifier | Muğla Sıtkı Koçman University Clinical Research Ethics Committee |
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| Name | Class |
|---|---|
| Muğla Sıtkı Koçman University | OTHER |
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The goal of this randomized controlled trial was to learn whether a combined aerobic and resistance exercise program could improve physical function and muscle health in people receiving peritoneal dialysis. Researchers compared an exercise group with a control group to evaluate the effects of regular exercise.
The main questions the study aimed to answer were:
Before the exercise program, participants completed a one-month training period to learn the exercises and practice them safely.
Participants in the exercise group:
Participants in the control group:
People receiving peritoneal dialysis often experience reduced physical function, muscle weakness, and changes in body composition. This randomized controlled trial evaluated the effects of a combined aerobic and resistance exercise program in adults receiving peritoneal dialysis.
Before the intervention, participants completed a one-month training and adaptation period to learn the exercises and ensure safe participation. Participants were then assigned to either an exercise group or a control group. The exercise group performed a structured combined aerobic and resistance exercise program for 8 weeks, while the control group continued usual care.
Researchers evaluated physical performance, muscle strength, body composition, and blood markers related to muscle health before and after the intervention period. The study aimed to determine whether regular exercise could improve physical function and muscle health in people receiving peritoneal dialysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| exercise group | Experimental | Participants performed a combined aerobic and resistance exercise program for 8 weeks. |
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| control group | No Intervention | Participants continued their usual care during the study period without a structured exercise program. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Combined Aerobic and Resistance Exercise | Behavioral | Participants performed a structured combined aerobic and resistance exercise program for 8 weeks. Before the intervention period, participants completed a one-month training and adaptation phase to learn the exercises and ensure safe participation. The exercise program aimed to improve physical performance, muscle strength, and muscle health in people receiving peritoneal dialysis. |
| Measure | Description | Time Frame |
|---|---|---|
| Physical Performance | Changes in physical performance assessed using the 6-minute walk test after 8 weeks of combined aerobic and resistance exercise. | Baseline and after 8 weeks of intervention |
| Changes in right handgrip strength | Changes in right handgrip strength measured in kilograms after 8 weeks of combined aerobic and resistance exercise. | Baseline and after 8 weeks of intervention |
| Changes in left handgrip strength | Changes in left handgrip strength measured in kilograms after 8 weeks of combined aerobic and resistance exercise. | Baseline and after 8 weeks of intervention |
| Changes in leg strength | Changes in lower extremity muscle strength measured using a leg and back dynamometer after 8 weeks of combined aerobic and resistance exercise. | Baseline and after 8 weeks of intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in flexibility | Changes in flexibility assessed using the Modified Back-Saver Sit-and-Reach Test after 8 weeks of combined aerobic and resistance exercise. | Baseline and after 8 weeks of intervention |
| Changes in Fat Tissue Index (FTI) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in biceps skinfold thickness | Changes in biceps skinfold thickness measured using skinfold caliper assessment after 8 weeks of combined aerobic and resistance exercise. | Baseline and after 8 weeks of intervention |
| Changes in triceps skinfold thickness |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mugla Sitki Kocman University Faculty of Medicine, Mugla Training and Research Hospital | Muğla | Muğla | 48000 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31480056 | Background | Lu Y, Wang Y, Lu Q. Effects of Exercise on Muscle Fitness in Dialysis Patients: A Systematic Review and Meta-Analysis. Am J Nephrol. 2019;50(4):291-302. doi: 10.1159/000502635. Epub 2019 Sep 3. | |
| 21975737 | Background | Heiwe S, Jacobson SH. Exercise training for adults with chronic kidney disease. Cochrane Database Syst Rev. 2011 Oct 5;2011(10):CD003236. doi: 10.1002/14651858.CD003236.pub2. |
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Individual participant data will not be shared to protect participant privacy and confidentiality.
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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Participants were assigned to either an exercise group or a control group and followed in parallel throughout the study period
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Changes in Fat Tissue Index measured by by bioimpedance spectroscopy after 8 weeks of combined aerobic and resistance exercise.
| Baseline and after 8 weeks of intervention |
| Changes in Lean Tissue Index (LTI) | Changes in Lean Tissue Index measured by by bioimpedance spectroscopy after 8 weeks of combined aerobic and resistance exercise. | Baseline and after 8 weeks of intervention |
| Changes in serum IGF-1 levels | Changes in serum insulin-like growth factor-1 (IGF-1) levels after 8 weeks of combined aerobic and resistance exercise. | Baseline and after 8 weeks of intervention |
| Changes in serum ACTH levels | Changes in serum adrenocorticotropic hormone (ACTH) levels after 8 weeks of combined aerobic and resistance exercise. | Baseline and after 8 weeks of intervention |
| Changes in serum myostatin levels | Changes in serum myostatin levels after 8 weeks of combined aerobic and resistance exercise. | Baseline and after 8 weeks of intervention |
| Changes in serum irisin levels | Changes in serum irisin levels after 8 weeks of combined aerobic and resistance exercise. | Baseline and after 8 weeks of intervention |
Changes in triceps skinfold thickness measured using skinfold caliper assessment after 8 weeks of combined aerobic and resistance exercise. |
| Baseline and after 8 weeks of intervention |
| Changes in abdominal skinfold thickness | Changes in abdominal skinfold thickness measured using skinfold caliper assessment after 8 weeks of combined aerobic and resistance exercise. | Baseline and after 8 weeks of intervention |
| 30796338 | Background | Uchiyama K, Washida N, Morimoto K, Muraoka K, Kasai T, Yamaki K, Miyashita K, Wakino S, Itoh H. Home-based Aerobic Exercise and Resistance Training in Peritoneal Dialysis Patients: A Randomized Controlled Trial. Sci Rep. 2019 Feb 22;9(1):2632. doi: 10.1038/s41598-019-39074-9. |