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The goal of this observational study is to learn whether hazardous alcohol consumption, measured objectively by carbohydrate-deficient transferrin (CDT) levels at intensive care unit (ICU) admission, is associated with worse outcomes in critically ill patients. The main question it aims to answer is:
Do elevated CDT levels at ICU admission predict increased short-term mortality and adverse clinical outcomes in adult non-traumatic ICU patients? Participants admitted to the intensive care unit via the emergency department will have CDT levels measured as part of the study. Researchers will then collect and analyze clinical data, including mortality, duration of mechanical ventilation, delirium, ICU length of stay, renal replacement therapy, and ICU readmission rates, during hospitalization and follow-up.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Carbohydrate-Deficient Transferrin (CDT) Measurement | Diagnostic Test | Carbohydrate-deficient transferrin (CDT) measurement is performed at ICU admission as an objective biomarker of sustained hazardous alcohol consumption during the previous 1-3 weeks. CDT values are obtained from routinely collected blood samples in adult non-traumatic ICU patients admitted via the emergency department. The study is purely observational and does not involve administration of a therapeutic intervention or changes to standard clinical care. CDT levels are analyzed in relation to outcomes including 30-day mortality, ICU length of stay, mechanical ventilation, delirium, renal replacement therapy, and ICU readmission. |
| Measure | Description | Time Frame |
|---|---|---|
| The primary outcome of the study is 30-day all-cause mortality in ICU patients. | 30-day all-cause mortality is defined as death from any cause occurring within 30 days after ICU admission. Mortality status will be assessed using patient medical records and, if unavailable, through the Austrian "Zentrales Personenstandsregister" (Central Civil Status Register), which documents registered deaths. Outcomes will be compared between patients with elevated and non-elevated carbohydrate-deficient transferrin (CDT) levels measured at ICU admission. | From ICU admission to 30 days after ICU admission |
| Measure | Description | Time Frame |
|---|---|---|
| In-hospital mortality | Death from any cause occurring during the index hospital stay. | From hospital admission to hospital discharge evaluated 6 Months after study inclusion |
| ICU length of stay |
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Inclusion Criteria:
Exclusion Criteria:
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Study participants will be selected from adult patients admitted to the Department of Emergency Medicine who are subsequently transferred to an in-house intensive care unit (ICU). The study population consists of critically ill non-traumatic ICU patients receiving routine emergency and intensive care treatment.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Juergen Grafeneder, MD, PhD MSc | Contact | â€+43 1 4040019640‬ | juergen.grafeneder@meduniwien.ac.at |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Vienna | Recruiting | Vienna | Austria |
De-identified individual participant data (IPD) underlying the reported study results, including demographic characteristics, laboratory values, CDT measurements, clinical parameters, and outcome data, may be shared upon reasonable request after publication of the primary results. Data containing directly identifiable personal information will not be shared in order to protect participant privacy and comply with applicable data protection regulations. Requests for access will be evaluated by the study investigators and institutional authorities.
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| ID | Term |
|---|---|
| D016638 | Critical Illness |
| D019973 | Alcohol-Related Disorders |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019966 | Substance-Related Disorders |
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Duration of stay in the intensive care unit, measured in days from ICU admission to ICU discharge.
| From ICU admission to ICU discharge evaluated 6 Months after study inclusion |
| Duration of mechanical ventilation | Total duration of mechanical ventilation during the ICU stay, measured in hours or days. | From initiation of mechanical ventilation to successful discontinuation during ICU stay evaluated 6 Months after study inclusion |
| Illness severity score | Severity of illness assessed using TISS(-A), with a higher score signaling higher severity | Evaluated from the documentation 6 Months after study inclusion |
| Illness severity score | Severity of illness assessed using APACHE II , with a higher score signaling higher severity | Evaluated from the documentation 6 Months after study inclusion |
| Illness severity score | Severity of illness assessed using SAPS II, with a higher score signaling higher severity | Evaluated from the documentation 6 Months after study inclusion |
| Illness severity score | Severity of illness assessed using SOFA scores, with a higher score signaling higher severity | Evaluated from the documentation 6 Months after study inclusion |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |