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Based on the bioholographic theory, this study preliminarily explores the clinical efficacy of hand acupuncture in treating acute exacerbation of bronchial asthma and evaluates its immediate anti-asthmatic effect, so as to provide a new therapeutic strategy for the clinical management of bronchial asthma.
This study adopted a randomized controlled trial design, with patients in the acute exacerbation phase of bronchial asthma as the research subjects. A total of 72 patients who met the inclusion criteria were randomly divided into the acupuncture group and the control group in a 1:1 ratio. The control group received standard Western medicine treatment, while the acupuncture group was given acupuncture treatment based on biological holography theory in addition to the standard Western medicine treatment. The acupoints selected were Kechuan point, New Kechuan point, and Yuji point. The treatment was administered once a day for 20 minutes each time, for 5 consecutive days, with a 3-month follow-up. The therapeutic efficacy of manual acupuncture in treating acute exacerbation of bronchial asthma was evaluated with indicators including symptom and sign scores, pulmonary function, ACT , mMRC , Mini-AQLQ scale, serum interleukin-4 (IL-4), serum eotaxin and specific immunoglobulin E (SIgE). In addition, the underlying therapeutic mechanism was preliminarily explored to formulate a technical protocol for rapid anti-asthma acupuncture, laying a foundation for long-term and objective efficacy evaluation of this therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| acupuncture group | Experimental | The acupuncture group was given acupuncture treatment based on biological holography theory in addition to the standard Western medicine treatment. The acupoints selected were Kechuan point, New Kechuan point, and Yuji point. The treatment was administered once a day for 20 minutes each time, for 5 consecutive days |
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| control group | Active Comparator | The control group received standard Western medicine treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acupuncture | Other | The acupoints selected were Kechuan point, New Kechuan point, and Yuji point. The treatment was administered once a day for 20 minutes each time, for 5 consecutive days. |
| Measure | Description | Time Frame |
|---|---|---|
| Peak Expiratory Flow(PEF) | PEF will be used to assess pulmonary function | After treatment on Day 5 and follow-up at 1, 2 and 3 months |
| Asthma Control Test | The ACT score consists of 5 questions, each scored from 1 to 5 points, with a total score ranging from 5 to 25 points; lower scores indicate more severe symptoms. | After treatment on Day 5 and follow-up at 1, 2 and 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Forced expiratory volume in first second/pred（FEV1%pred） | FEV1%pred will be used to assess pulmonary function | After treatment on Day 5 and follow-up at 1, 2 and 3 months |
| Clinical Symptom and Sign Score |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Qinmei Yang | Contact | 15981845716 | yangqinmei840105@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the First Affiliated Hospital of Henan University of Chinese Medicine | Recruiting | Zhengzhou | Henan | 450000 | China |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| ID | Term |
|---|---|
| D015670 | Acupuncture Therapy |
| ID | Term |
|---|---|
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
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| Standard Western medicine treatment | Drug | Evaluate and manage in accordance with the Chinese Expert Consensus on Assessment and Management of Acute Exacerbation of Bronchial Asthma issued by the Asthma Group of the Chinese Thoracic Society, Chinese Medical Association in 2018 and the Guidelines for the Prevention and Treatment of Bronchial Asthma (2020 ). |
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It includes six symptoms: cough, expectoration, chest tightness, wheezing, shortness of breath and wheeze. Scores of 0, 3, 6 and 9 are assigned according to the severity of symptoms, with higher scores corresponding to more severe symptoms.
| After treatment on Day 5 and follow-up at 1, 2 and 3 months |
| Mini Asthma Quality of Life Questionnaire（Mini-AQLQ) | It consists of 15 questions, each scored on a scale from 1 to 7 based on the severity of symptoms and their degree of impact. A score of 1 indicates no symptoms or no adverse impacts, while a score of 7 stands for severe symptoms or substantial impairment. Lower total scores correspond to a higher quality of life. | After treatment on Day 5 and follow-up at 1, 2 and 3 months |
| modified Medical Research Council (mMRC) | Scores range from 0 to 4 based on the severity of dyspnea, with higher scores indicating more severe symptoms. | After treatment on Day 5 and follow-up at 1, 2 and 3 months |
| Interleukin 4 (IL-4) | Detect the level of IL-4 in peripheral blood | After treatment on Day 5 |
| Eotaxin | Detect the level of Eotaxin in peripheral blood | After treatment on Day 5 |
| IgE | Detect the level of IgE in peripheral blood | After treatment on Day 5 |
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |