Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 2026-A01255-46 | Other Identifier | ID-RCB number |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of this study is to determine whether the diffuse cerebral metabolic disturbances observed in glioblastoma are exclusively linked to the direct and indirect effects of tumor infiltration (particularly structural disconnection), or whether they also reflect a more global alteration of neurometabolic and neurovascular coupling mechanisms.
This approach thus aims to better understand the pathophysiological basis of cognitive impairment in glioblastoma and to characterize the impact of the disease at the level of brain networks.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with glioblastoma treated in the Department of Nuclear Medicine & Molecular Imaging | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 18F-FDG PET/MRI with additional DTI and rs-fMRI sequences | Other | fluorodeoxyglucose (Fluor18) (18F-FDG) PET/MRI with additional DTI and rs-fMRI sequences correlation with neuropsychological tests |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between cortical energy activity (FDG PET), axonal morphological connectivity (DTI - MRI), synchronous neuronal activity (rs-fMRI), and preoperative neuropsychological performance before surgery | Before surgery |
| Measure | Description | Time Frame |
|---|---|---|
| correlation between cortical energy activity (FDG PET), axonal morphological connectivity (DTI - MRI), synchronous neuronal activity (rs-fMRI), and preoperative neuropsychological performance after surgery | After surgery, through the study, i.e. for a maximum of 2 years |
Not provided
Inclusion Criteria:
Adult patients
Patients with glioblastoma
Patients treated in the Nuclear Medicine & Molecular Imaging Department of the Strauss Institute for PET/MRI scans for:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Claire VIT | Contact | (0)388258529 | +33 | promotion-rc@institut-strauss.fr |
| Manon VOEGELIN | Contact | (0)368339523 | +33 | promotion-rc@institut-strauss.fr |
| Name | Affiliation | Role |
|---|---|---|
| Izzie-Jacques NAMER, MD, PhD | Institut Public De Cancerologie Strauss Europe | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut public de cancérologie Strauss Europe | Strasbourg | 67033 | France |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D005909 | Glioblastoma |
| ID | Term |
|---|---|
| D001254 | Astrocytoma |
| D005910 | Glioma |
| D018302 | Neoplasms, Neuroepithelial |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009380 | Neoplasms, Nerve Tissue |
Not provided
Not provided