This study aims to evaluate the effectiveness of a health literacy promotion program in preventing chronic kidney disease (CKD) among patients who use multiple medications (polypharmacy). Participants will be divided into two groups: an experimental group receiving the health literacy program and a control group receiving standard care. The study will measure improvements in health literacy levels and CKD prevention behaviors over a specific period. It is expected that the program will help patients better manage their medications and reduce the risk of developing kidney complications.

Background: Patients with polypharmacy are at a higher risk of drug-induced kidney injury. Enhancing health literacy is a key strategy to empower these patients to engage in protective health behaviors.

Objectives: 1) To compare health literacy scores before and after participating in the program. 2) To compare CKD prevention behaviors between the experimental and control groups.

Methodology: This is a quasi-experimental study with a pre-test/post-test design.

Experimental Group: Receives the "Health Literacy Promotion Program," which includes educational sessions, skill-building for medication management, and follow-up support.

Control Group: Receives routine nursing care and standard health education. Intervention Details: The program focuses on 6 aspects of health literacy: access, understanding, communication, questioning, decision-making, and practice.

Data Collection: Data will be collected using validated questionnaires for health literacy and CKD prevention behavior at baseline and after the intervention (e.g., at week 12).

Analysis: Descriptive statistics and t-tests (Independent and Paired) will be used to evaluate the program's effectiveness.

Inclusion Criteria:

• Patients aged 55-74 years diagnosed with non-communicable diseases.
• Currently taking 5 or more medications daily (Polypharmacy) for at least 6 months.
• Have at least one risk factor for chronic kidney disease (e.g., Hypertension or Diabetes).
• Able to communicate, read, and write in Thai.
• Willing to participate in the 8-week program and follow-up assessments.

Exclusion Criteria:

• Patients already diagnosed with Chronic Kidney Disease (CKD) stage 3 - 5.
• Having severe cognitive impairment or psychiatric disorders that prevent participation.
• Having severe complications or being in an unstable clinical condition.
• Planning to move out of the study area during the 12-week study period.

Individual participant data will not be shared to protect the privacy and confidentiality of the participants, in accordance with the informed consent and institutional ethical guidelines.

The outcome assessor, who is responsible for data collection and evaluation, is blinded to the group assignment to minimize assessment bias.