The present study aims at comprehensively assessing the diagnostic performance and safety profile of EUS-FNB as a primary diagnostic tool for suspected malignancies in anatomically complex or deeply situated regions, including the duodeno-jejunal, and hepatic hilar areas. By focusing on lesions that are challenging to reach due to their intricate anatomy or profound depth, investigators seek to provide valuable insights into the potential role of EUS-FNB in enhancing diagnostic accuracy and safety in these complex clinical scenarios.

Inclusion Criteria:

1. age ≥ 18 years;
2. patients with one or multiple lesions adjacent to the distal duodenum, or the proximal jejunum, or the hepatic hilum that underwent EUS in our Institution over the past 10 years;
3. Patients monitored for at least 6 months after EUS-FNB or until death (follow-up less than 6 months);
4. Available data;
5. Written informed consent.

Exclusion Criteria:

1. Age less than 18 years old;
2. Patient unable to sign the informed consent.

Data on all the consecutive EUS performed for para-duodenal, para-jejunal land hepatic hilum lesions in our Unit between January 2013 and June 2023 will be retrospectively reviewed.

Telephone contact will be performed if additional information is required to fulfil the Case Report Forms (CRF). CRFs will be used to collect the data. CRFs are fully anonymized using a progressive alphanumeric identification code and the age instead of the date of birth. CRFs will be translated into an electronic spreadsheet.