Intraosseous Antibiotics for Osseointegration

Intraosseous Antibiotics for Osseointegration

The purpose of this research study is to learn about the characteristics of infection in osseointegration patients. This research study will also study how safe and effective it is to use antibiotics inside the bone.

The goal of this multi-center prospective trial is to assess the characteristics of infection among patients with osseointegrated prosthesis and the safety and effectiveness of intraosseous antibiotic delivery.

Participants will enroll in an observational arm. Participants who require surgery for infection may enroll in an interventional arm assessing the safety and feasibility of intraosseous antibiotic administration as a potential treatment for infection.

Inclusion Criteria:

• Treated with osseointegration for transfemoral, transhumeral, or transtibial amputation and presenting with concern for surgical site infection
• >18 years of age

Exclusion Criteria:

• Unable to follow up at site for 1 year
• Patients that speak neither English nor Spanish
• <18 years of age