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| ID | Type | Description | Link |
|---|---|---|---|
| Ratchadapisek Postdoctoral | Other Grant/Funding Number | Chulalongkorn University |
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Obesity is associated with impaired vascular function, metabolic dysfunction, and reduced physical fitness, which increase cardiovascular disease risk. This randomized controlled trial aims to investigate the effects of a 12-week home-based circuit training program using light-to-moderate resistance on vascular health, body composition, metabolic function, resting metabolic rate, substrate oxidation, physical activity, and physical fitness in adults with obesity. Participants will be randomly assigned to either a home-based circuit training group or a control group maintaining usual daily activities. The findings may support the use of home-based exercise as a practical and time-efficient strategy for obesity management and cardiovascular risk reduction.
Obesity is a major public health concern associated with endothelial dysfunction, arterial stiffness, metabolic impairment, and reduced physical fitness. Although exercise training is recommended for obesity management, adherence to supervised exercise programs may be limited by time constraints and accessibility. Home-based circuit training may provide a feasible alternative that combines aerobic and resistance exercise within a time-efficient format.
This randomized controlled trial investigates the effects of a 12-week home-based circuit training intervention on vascular function, body composition, metabolic function, resting metabolic rate, substrate oxidation, physical activity, and physical fitness in adults with obesity.
Participants with obesity (BMI ≥ 27.5 kg/m²) will be randomly assigned to either a circuit training group or a control group. The intervention group will perform home-based circuit training using light-to-moderate resistance three times weekly for 12 weeks, while the control group will maintain usual activities.
Primary vascular outcomes include flow-mediated dilation, carotid intima-media thickness, brachial-ankle pulse wave velocity, and post-occlusive reactive hyperemia. Secondary outcomes include body composition, fasting plasma glucose, resting metabolic rate, substrate oxidation, physical activity, muscular strength, flexibility, and cardiorespiratory fitness.
The study aims to determine whether home-based circuit training can improve vascular and metabolic health and serve as a practical strategy for reducing cardiovascular risk in adults with obesity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Home-Based Circuit Training | Experimental | Participants in this group will perform a 12-week home-based circuit training program three times per week. Each session includes warm-up, circuit exercise, and cool-down components designed to improve vascular and metabolic health. |
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| Control Group | No Intervention | participants in the control group will maintain their usual daily activities without participating in the exercise intervention during the study period. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Home-Based Circuit Training | Behavioral | Participants will perform a 12-week home-based circuit training program three times per week. Each session includes warm-up, circuit-based exercises targeting major muscle groups, and cool-down activities. The intervention is designed to improve vascular and metabolic health in adults with obesity. The training program consisted of two phases: phase 1 (weeks 1-6) and phase 2 (weeks 7-12). During phase 1, participants performed resistance exercises at an intensity of 65-70% of one-repetition maximum (1RM). Each exercise consisted of 12 repetitions, with a 1-minute rest between exercises. The lifting tempo was maintained at 2:2 (concentric: eccentric). Participants completed 8 exercises per circuit for a total of 3 circuits, with a 2-minute rest between circuits. During phase 2, the intensity was increased to 70-75% of 1RM, while maintaining 12 repetitions per exercise. The rest interval between exercises was reduced to 30 seconds, with the same lifting tempo (2:2). Participants complete |
| Measure | Description | Time Frame |
|---|---|---|
| Vascular Function | Change in flow-mediated dilation from baseline to 12 weeks. | Baseline and 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Daroonwan Suksom, PhD | Faculty of Sports Science, Chulalongkorn University, Bangkok, Thailand | Study Director |
| Tunyakarn Worasettawat, PhD | Faculty of Sports Science, Chulalongkorn University, Bangkok, Thailand | Principal Investigator |
| Hirofumi Tanaka, PhD | Department of Kinesiology and Health Education, The University of Texas at Austin, USA | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Sports Science, Chulalongkorn University | Bangkok | ฺBangkok | 10330 | Thailand |
Individual participant data (IPD) may be shared upon reasonable request after publication of the study results and approval by the principal investigator.
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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Participants will be randomly assigned to either a home-based circuit training group or a control group in a parallel-group design.
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| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |