Odontogenic Graft Obtained From Human Tooth and Low Level Laser Therapy

Use of Odontogenic Graft Obtained From Human Tooth and Low Level Laser Therapy

This clinical trial aims to evaluate the effectiveness of an odontogenic graft obtained from extracted human teeth, with and without adjunctive low-level laser therapy (LLLT), on bone regeneration following posterior tooth extraction in systemically healthy adult patients. The study investigates whether the combination of autogenous tooth-derived graft material and LLLT enhances alveolar bone healing and preservation compared to grafting alone, prior to implant-supported posterior rehabilitation.

This prospective clinical trial will include systemically healthy adult patients who require extraction of at least two posterior teeth with a hopeless prognosis due to periodontal disease, root caries, or root fractures, and who are candidates for implant-supported posterior rehabilitation. Following atraumatic tooth extraction, only sites with intact alveolar socket walls will be included.

Extracted teeth will be processed to obtain an autogenous odontogenic graft material. Eligible extraction sockets will be allocated to one of the study groups: (1) odontogenic graft alone or (2) odontogenic graft combined with adjunctive low-level laser therapy. In the laser group, LLLT will be applied according to a standardized protocol during the early healing period to promote cellular activity and bone regeneration.

Clinical and radiographic evaluations will be performed at baseline and at predefined follow-up intervals to assess soft tissue healing, bone dimensional changes, and quality of regenerated bone prior to implant placement. The primary outcome measure will be the amount and quality of newly formed bone, while secondary outcomes will include socket healing, postoperative morbidity, and implant feasibility.

The results of this study aim to provide clinical evidence on the potential benefits of combining autogenous tooth-derived grafts with low-level laser therapy for alveolar ridge preservation and to support optimized treatment protocols for implant-supported posterior rehabilitation.

Inclusion Criteria:

• Patients requiring tooth extraction due to periodontal reasons (teeth with a hopeless prognosis), root caries, or root fractures, who are simultaneously candidates for posterior replacement with an osseointegrated implant, and who require extraction of at least two teeth.
• Integrity of the alveolar socket walls following tooth extraction.
• Patients who accept the study conditions, sign written informed consent, and agree to attend the scheduled follow-up visits.

Exclusion Criteria:

• General contraindications for dental and/or surgical treatments.
• Inflammatory or autoimmune diseases of the oral cavity.
• Uncontrolled diabetes mellitus (HbA1c > 7%).
• History of malignancy requiring chemotherapy or radiotherapy within the past 5 years.
• Previous treatment with immunosuppressive agents, bisphosphonates, or high-dose corticosteroids.
• Smoking more than 10 cigarettes per day.
• Pregnant or breastfeeding women.