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This randomized controlled trial aims to evaluate the effects of different ratios of electrolyte beverage and water combined with polyethylene glycol (PEG) on bowel preparation quality before colonoscopy. Participants undergoing elective colonoscopy will be randomly assigned to one of three bowel preparation regimens: PEG prepared with water only, PEG prepared with a low ratio of electrolyte beverage and water, or PEG prepared with a medium ratio of electrolyte beverage and water. The primary outcome is adequate bowel preparation assessed by the Boston Bowel Preparation Scale (BBPS). Secondary outcomes include bowel preparation completion rate, tolerability, adverse events, repeat colonoscopy rate, adenoma detection rate, and ingestion rhythm characteristics during bowel preparation. This study also aims to explore whether electrolyte beverage-assisted bowel preparation may improve bowel cleansing quality by influencing participants' ingestion rhythm and adherence during PEG intake.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Water Group | Active Comparator | Participants receive polyethylene glycol (PEG) prepared with water only for bowel preparation before colonoscopy. |
|
| Low-dose Electrolyte Beverage Group | Experimental | Participants receive polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:3 ratio for bowel preparation before colonoscopy. |
|
| Medium-dose Electrolyte Beverage Group | Experimental | Participants receive polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:1 ratio for bowel preparation before colonoscopy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PEG With Water | Other | Polyethylene glycol (PEG) prepared with water only for bowel preparation before colonoscopy. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Adequate Bowel Preparation Rate | Adequate bowel preparation is defined as a total Boston Bowel Preparation Scale (BBPS) score ≥6 with each colonic segment score ≥2 during colonoscopy. | At the time of colonoscopy on Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Total Boston Bowel Preparation Scale Score | Total Boston Bowel Preparation Scale (BBPS) score assessed during colonoscopy. | At the time of colonoscopy on Day 1 |
| Bowel Preparation Completion Rate |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Aimin Li | Contact | +86 13580317630 | lam0725@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nanfang Hospital, Southern Medical University | Recruiting | Guangzhou | Guangdong | China |
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| PEG With Low-dose Electrolyte Beverage | Other | Polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:3 ratio for bowel preparation before colonoscopy. |
|
| PEG With Medium-dose Electrolyte Beverage | Other | Polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:1 ratio for bowel preparation before colonoscopy. |
|
Proportion of participants who complete the planned polyethylene glycol bowel preparation within 60 minutes.
| During bowel preparation within 1 hour before colonoscopy on Day 1 |
| Adverse Event Rate | Incidence of adverse events during bowel preparation, including nausea, vomiting, abdominal distension, abdominal pain, dizziness, and fatigue. | During bowel preparation within 1 hour before colonoscopy on Day 1 |
| ID | Term |
|---|---|
| D014867 | Water |
| ID | Term |
|---|---|
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |
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