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Doctors use patterns on heart rhythm tracings (ECGs) to predict where abnormal heart rhythms originate, but these prediction methods were developed in people with normal heart structure. Patients with repaired Tetralogy of Fallot have hearts that developed differently, and cardiologists do not know if these prediction methods work accurately for them. In this study, the investigators will test whether three commonly used prediction methods work in Tetralogy of Fallot patients by pacing the heart from known locations during an already-scheduled heart procedure and comparing the predicted location to the actual location. Participation adds approximately 15 minutes to the procedure and does not require additional visits. The results will help cardiologists understand whether current methods can be trusted when planning treatments for abnormal heart rhythms in this patient population, or whether new prediction methods need to be developed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pace Mapping | Experimental | Patients presenting for clinically-indicated EP study will undergo systematic pace mapping from RV and LV sites according to published PVC/VT localization algorithm schema. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| RV and LV pace mapping | Diagnostic Test | Pace mapping at systematic RV and LV sites according to select published VT/PVC localization schema will be performed in study patients. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Algorithm accuracy (%) | The proportion of correctly identified pace sites among all evaluable pace sites, and analyzed separately for each algorithm according to its intended classification scheme. Concordance at each pace site will be assessed as a binary outcome. | From enrollment to completion of the pacing protocol during their EP study. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Edward T O'Leary, MD | Contact | 617-355-7833 | edward.oleary@cardio.chboston.org |
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| ID | Term |
|---|---|
| D013771 | Tetralogy of Fallot |
| D017180 | Tachycardia, Ventricular |
| ID | Term |
|---|---|
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
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| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D013610 | Tachycardia |
| D001145 | Arrhythmias, Cardiac |
| D000075224 | Cardiac Conduction System Disease |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |