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| Name | Class |
|---|---|
| Poitiers University Hospital | OTHER |
| Laboratory MOVE, Faculty of Sport Sciences, University of Poitiers, France | UNKNOWN |
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Hypertension during pregnancy is a major public health concern, increasing the risk of cardiovascular complications for both the mother and the fetus. Women with chronic hypertension are at higher risk of adverse outcomes, and elevated blood pressure during pregnancy has also been associated with long-term cardiovascular and cognitive impairments.Regular physical activity is recognized as an effective non-pharmacological strategy to reduce blood pressure. Among different exercise modalities, isometric exercise has shown promising effects in lowering blood pressure in the general population, with minimal cardiovascular strain. However, its effects and safety in pregnant women, particularly those with hypertension, remain poorly understood.In addition to cardiovascular alterations, hypertension during pregnancy may also impact cognitive function, potentially through changes in cerebral perfusion and vascular function. Despite these associations, the combined cardiovascular and cognitive responses to exercise in this population have not been fully explored.This study aims to investigate the effects of isometric handgrip exercise on cardiovascular and cognitive responses in pregnant women with and without chronic hypertension, in order to better understand its potential as a safe and effective non-pharmacological intervention during pregnancy.
Hypertension during pregnancy is a major public health concern associated with increased maternal and fetal morbidity, and long-term cardiovascular risk. Women with chronic hypertension are at higher risk of complications such as preeclampsia, preterm birth, and adverse neonatal outcomes. In addition, growing evidence suggests that hypertensive disorders of pregnancy may also be associated with long-term alterations in cardiovascular function and cognitive performance.During pregnancy, physiological changes in blood pressure regulation and vascular function may further complicate the management of hypertension. Pharmacological treatment options are limited due to potential risks for the fetus, highlighting the need for safe and effective non-pharmacological strategies.Physical exercise is recognized as an effective approach to reduce blood pressure and improve cardiovascular health in the general population. Among the different exercise modalities, isometric exercise has shown particularly promising effects in reducing blood pressure, with a low cardiovascular load. This modality may therefore represent an attractive option for pregnant women, as it can be performed safely with minimal physiological stress. However, despite these potential benefits, the effects and safety of isometric exercise during pregnancy, particularly in hypertensive women, remain poorly understood.In addition to cardiovascular alterations, hypertension during pregnancy may impact cognitive function, potentially through changes in cerebral perfusion and vascular regulation. Although physical activity has been associated with improvements in cognitive performance in the general population, the acute effects of exercise on cognitive function during pregnancy have not been well established.The aims of this study are:First, to evaluate the effect of isometric handgrip exercise on 24-hour blood pressure in pregnant women with and without chronic hypertension.Second, to compare cardiovascular responses to isometric exercise between normotensive and hypertensive pregnant women, including brachial and central blood pressure, arterial stiffness, and heart rate.Third, to examine differences in cognitive performance between normotensive and hypertensive pregnant women, and to explore the relationship between cardiovascular responses and cognitive outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normotensive Pregnant Women | Other | Pregnant women without chronic hypertension. Participants in this arm complete both the isometric handgrip exercise session and the control rest session in randomized order. |
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| Hypertensive Pregnant Women | Other | Pregnant women with chronic untreated hypertension. Participants in this arm complete both the isometric handgrip exercise session and the control rest session in randomized order. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Isometric Handgrip Exercise | Behavioral | Isometric handgrip exercise performed at 30% of maximal voluntary contraction, consisting of four 2-minute contractions with one-minute rest intervals between efforts. The exercise is performed using a handgrip dynamometer. |
| Measure | Description | Time Frame |
|---|---|---|
| Systolic and diastolic blood pressure (ambulatory blood pressure measurement) | Post-exercise hypotension, using the Mobil-O-Graph (mmHg). | After sessions (24 hours) |
| Measure | Description | Time Frame |
|---|---|---|
| Systolic and diastolic blood pressure (resting) | Automated oscillometric tensiometer (mmHg) | Before and after sessions (15 minutes) |
| Central blood pressure | Central systolic and diastolic blood pressure assessed using pulse wave analysis derived from brachial oscillometric measurements. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carina ENEA | Contact | +33 549 454 495 | carina.enea@univ-poitiers.fr | |
| Mélanie Gréau Marias | Contact | +33 675 329 599 | melanie.greau.marias@univ-poitiers.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Sport Science - MOVE Laboratory - UR 20296 | Recruiting | Poitiers | 86000 | France |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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This is a randomized crossover study. Each participant completes two experimental conditions (isometric handgrip exercise and control rest) in a random order.
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| Control Rest | Behavioral | Seated rest condition without exercise, used as a control comparison to the isometric handgrip intervention. |
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| Baseline and post-intervention during sessions (30 minutes) |
| Pulse wave velocity | Arterial stiffness assessed by carotid-femoral pulse wave velocity using applanation tonometry. This measurement is performed at rest to characterize vascular health. | Baseline |
| Heart rate | Heart rate measured during each experimental session and recovery period using a heart rate monitor to assess cardiovascular response to the intervention. | Basline, before and after sessions (15 minutes) |
| Cognitive Performance | Cognitive performance assessed at rest using a neuropsychological test battery including executive function, memory, attention, and processing speed tests. This outcome is used to compare cognitive function between normotensive and hypertensive pregnant women.
| Baseline |