Local data regarding the effectiveness and safety of mannitol has been scarce. Therefore, the current study was planned, aiming to compare the change in mean anterior chamber depth and intraocular pressure (IOP) and to determine the frequencies of perioperative complications during cataract surgery in groups receiving mannitol versus placebo.

The literature shows that the effectiveness of mannitol in decreasing intraocular pressure (IOP) varies widely. Although it rapidly lowers IOP in the majority of people, clinical results and the extent of the reduction differ depending on a number of factors. Mannitol can be detrimental for patients with pulmonary edema or severe heart failure (congestive heart failure) because it quickly draws fluid into the bloodstream, increasing intravascular volume. In addition to contributing to the local literature, the results of this study will aid in determining the true efficacy and safety of mannitol.

Inclusion Criteria:

• Patients of any gender
• Aged 30-80 years
• Undergoing cataract surgery

Exclusion Criteria:

• Patients with glaucoma, uveitis, or corneal pathology
• With trauma
• Previously had surgery
• With exfoliation syndrome
• Had iridotomies
• Had use of sympathetic α1 antagonist

Data can be shared on a reasonable request.