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Isoinertial training is emerging as a potentially effective strategy to improve strength and functionality in older people diagnosed with chronic obstructive pulmonary disease (COPD), due to its influence on muscle mass and neuromuscular efficiency. COPD is characterized by systemic alterations, including peripheral muscle dysfunction; which contributes to patient functional limitation, and reduces patients' quality of life. Isoinertial training may improve the physiological response to effort, and also promote functional performance in this population. Hence, the aim of this study is to evaluate the effect of an isoinertial training program on muscle strength and functional capacity in patients with COPD during an 8-week intervention.
To assess the effects of an isoinertial training programme on muscle strength and functional capacity in older people diagnosed with chronic obstructive pulmonary disease (COPD), in a randomized controlled clinical trial. Thirty participants diagnosed with moderate to severe COPD, over 50 years (50% men, 50% women), will be included to analyze possible differences in the training response compared to the control group. Participants will sign the informed consent and randomly assign to the intervention or control group. The intervention consists in a supervised isoinertial training program, while the control group will continue with the usual pulmonary rehabilitation program. Patients will be subjected to an initial assessment that include the application of tests of functional capacity, muscle strength, as well as clinical parameters and sociodemographic characteristics. The intervention will last 8 weeks, with a frequency of 2 to 3 sessions per week. The training program will include exercises aimed at strengthening the upper and lower limbs, using a isoinertial device with controlled load progression.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Supervised isoinertial training | Experimental | Participants will perform a supervised isoinertial training program during 8 weeks of follow-up |
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| Traditional rehabilitation | Active Comparator | Participants involved in the usual pulmonary rehabilitation program
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Isoinertial training | Device | Supervised isoinertial training:
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| Measure | Description | Time Frame |
|---|---|---|
| Change in upper limb muscle strength using the Hand Grip Test (HGT) | Manual grip strength will be evaluated by dynamometry, as an indicator of peripheral muscle strength in patients with COPD. | Baseline and 8-week follow-up |
| Change in functional capacity by 6-minute walk test (6MWT) | The distance covered for 6 minutes will be evaluated as an indicator of exercise tolerance and functional capacity. | Baseline and 8-week follow-up |
| Lower limb functional performance | The number of repetitions performed in 30 seconds will be recorded as an indicator of functional strength-endurance in the lower limbs | Baseline and 8-week follow-up |
| Change in functional mobility using the Timed Up and Go Test (TUG) | The time needed to get up from a chair, walk, turn and sit down again will be measured, as an indicator of mobility and functional risk. | Baseline and 8-week follow-up |
| Change in muscle quality index (MQI) | Muscle quality will be estimated using the MQI, which evaluates the muscle power of the lower limbs considering leg length, body mass, gravitational acceleration and time required to complete 10 sit-to-stand repetitions | Baseline and 8-week follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Change in functional performance using 5 Times Sit-to-Stand Test (5STS) | Time required to perform 5 repetitions of standing and sitting will be measured, as a complementary indicator of lower limb function | Baseline and 8-week follow-up |
| Change in health-related quality of life through The Saint George's Respiratory Questionnaire (SGRQ) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| David Murcia-Lesmes, PhD | Contact | +571 5460600 | david.murcia@docentes.umb.edu.co |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidad Manuela Beltrán | Recruiting | Bogotá | Bogotá, DC | 110231 | Colombia |
Data availability to external researchers is restricted to related project proposals upon request to the PI.
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D009043 | Motor Activity |
| D008171 | Lung Diseases |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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| Traditional rehabilitation (control group) | Other | Traditional treatment (control group)
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The SGRQ will be applied to assess the symptoms, activity and impact of the respiratory disease. This score ranges from 0 to 100 points, a higher score indicates poor health. |
| Baseline and 8-week follow-up |
| Changes in Body Mass Index (BMI) | Body mass index (BMI) will be assessed to characterize participants' anthropometric status. BMI will be calculated as body weight divided by height squared and expressed in kilograms per square meter (kg/m^2). | Baseline and 8-week follow-up |
| Changes in heart rate | Heart rate (bpm) will be measured using an automatic monitor | Baseline and 8-week follow-up |
| Changes in blood pressure | Diastolic and systolic blood pressure (mmHg) will be measured using a blood pressure monitor | Baseline and 8-week follow-up |
| Changes in oxygen saturation (SpO2) | Oxygen saturation (Percentage, %) will be measured using an oximeter. | Baseline and 8 week follow-up |
| Pulsar Unidad de Neumologia y Rehabilitación Pulmonar | Recruiting | Ibague | Ibagué | 730006 | Colombia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
| D008722 | Methods |