Evaluation of Liquorice Nanogel Versus Diode Laser as an... | NCT07602738

Studies
Evaluation of Liquorice Nanogel Versus Diode Laser as an Adjunctive Treatment for Patients With Periodontitis Stage Ⅲ.

NCT07602738

Sponsor

Al-Azhar University

Status

Completed

Last Update Posted

May 22, 2026Actual

Enrollment

27Actual

Phase

Phase 3

Conditions

Diode Laser Therapy
Periodontal Disease
Liquorice Nanogel

Interventions

Liquorice Nanogel
diode laser

Countries

Egypt

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

May 2026

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Jul 1, 2024Actual

Primary Completion Date

Sep 28, 2025Actual

Completion Date

Apr 1, 2026Actual

First Submitted Date

May 12, 2026

First Submission Date that Met QC Criteria

May 19, 2026

First Posted Date

May 22, 2026Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

May 19, 2026

Last Update Posted Date

May 22, 2026Actual

Sponsor/Collaborators Module

Responsible Party, by Official Title

Alaa Yousri Mohamed, Master Candidate of Oral and Dental Medicine and Periodontology Al Azhar University for girls, Al-Azhar UniversityPrincipal Investigator

Lead Sponsor

Al-Azhar UniversityOTHER

Collaborators

Not provided

Oversight Module

Has Data Monitoring Committee (DMC)

Yes

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

FDAAA801 Violation

Not provided

Description Module

Brief Summary

Evaluation of the effect of liquorice nanogel versus diode laser on periodontitis stage Ⅲ clinically and microbiologically by molecular analysis of porphyromonas gingivalis using real time PCR.

Detailed Description

Quantitative analysis technique using real time pcr (polymerase chain reaction) was done to detect presence of porphyromonas gingivalis. Pocket depth (PD), Plaque index (PI), gingival index (GI) and Clinical attachment level (CAL) were measured before work and after 3 months postoperatively.

Analysis was made from gingival crevicular fluid samples of the patients using gutta percha paper points.

Design Module

Study Type

Interventional

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Phase 3

Interventional Study Design

Allocation

Biospecimen

No data available

No data is available for this block.

Enrollment

27Actual

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
control group	Experimental	no drug was added to control group	Drug: Liquorice Nanogel Drug: diode laser
Liquorice Nanogel	Experimental	10% Liquorice was prepared in nanogel concentrate	Drug: Liquorice Nanogel Drug: diode laser
Diode laser	Experimental	Epic X 0.9watt device was used	Drug: Liquorice Nanogel Drug: diode laser

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Liquorice Nanogel	Drug	Real Time pcr was chosen to detect 16s gene concentration for porphyromonas gingivalis bacteria that is specific for Periodontitis Stage 3.	Diode laser

Measure	Description	Time Frame
Quantitative analysis using real time pcr		3 months

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Patient had Periodontitis stage III with pocket depth ≥ 6mm; indicated for periodontal surgery or CAL ≥ 5mm.
Patient agreed to the surgical procedure and clinical trial.
Age ranged between 18-50 years old.

Exclusion Criteria:

1: No previous drug was taken affecting bone metabolism. 2- Smoking. 3- Pregnant women and women with menopause. 4- Patients with psychological problems . 5- Patients with abnormal habits. 6- Patients with medical conditions as Diabetes or Hypertension.

Accepts Healthy Volunteers

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

50 Years

Standard Ages

Adult

Study Population

Not provided

Sampling Method

Not provided

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Not provided

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Alazhar University for Girls		Cairo	Cairo Governorate	00202	Egypt

IPD Sharing Statement Module

Plan to Share IPD

Undecided

Description

Not provided

Types

Not provided

Time Frame

Not provided

Access Criteria

Not provided

URL

Not provided

Condition Browse Module

MeSH Terms

ID	Term
D010510	Periodontal Diseases

Ancestor Terms

ID	Term
D009059	Mouth Diseases
D009057	Stomatognathic Diseases

Browse Leaves

Not provided

Browse Branches

Not provided

Intervention Browse Module

MeSH Terms

ID	Term
D054023	Lasers, Semiconductor

Ancestor Terms

ID	Term
D007834	Lasers
D055096	Optical Devices
D004864	Equipment and Supplies
D055618	Radiation Equipment and Supplies

Browse Leaves

Not provided

Browse Branches

Not provided

Intervention Model Description

Patient had Periodontitis stage III with pocket depth ≥ 6mm; indicated for periodontal surgery or CAL ≥ 5mm , Patient agreed to the surgical procedure and clinical trial, Age ranged between 18-50 years old.

No previous drug was taken affecting bone metabolism , No Smokers Pregnant women and women with menopause were excluded. Patients with psychological problems were excluded. Patients with abnormal habits were excluded . Patients with medical conditions as Diabetes or Hypertension were excluded.