Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery

Inhalational Versus Intravenous Anesthesia on Lung Injury After Major Surgery in Patients With Sepsis

This randomized controlled trial will compare the effects of intraoperative inhalational anesthesia versus intravenous anesthesia on postoperative lung injury in septic patients undergoing surgery. The primary goal is to determine if the choice of anesthetic technique influences the incidence or severity of this complication. Participants will be randomly assigned to one of the two anesthetic regimens during surgery. They will receive daily in-hospital assessments for lung injury and other outcomes and will be followed for clinical outcomes until 90 days after the procedure.

Inclusion Criteria:

1. Age ≥ 18 years.
2. Diagnosis of sepsis according to Sepsis-3.0 (highly suspected or confirmed infection with acute increase in SOFA score ≥ 2).
3. Scheduled to undergo surgery under general aaesthesia for source control or sepsis-related operative management.

Exclusion Criteria:

1. Already intubated prior to entering the operating room.
2. Chronic home ventilator dependence (e.g., severe chronic obstructive pulmonary disease) before surgery.
3. Personal or family history of malignant hyperthermia.
4. Known allergy to ciprofol or sevoflurane.
5. Known allergy to egg or soy products.
6. Any contraindication to the planned anaesthetic agents.
7. Pregnant women.