Diagnostic Performance and Quantitative Analysis of [18F]FET PET in Brain Tumours

Diagnostic Performance and Quantitative Analysis of [18F]FET PET in Brain Tumours

This is a retrospective study encompassing all [18F]FET PET scans performed at our centre. By analysing both static and dynamic scans, conducting in-depth kinetic modelling, and comparing quantitative parameters across different tumour types and clinical contexts, the study aims to determine the true diagnostic value of [18F]FET PET in everyday clinical practice. The ultimate goal is to identify imaging biomarkers useful for improving tumour characterisation and distinguishing recurrence from post-treatment changes, thereby strengthening the role of [18F]FET PET in modern neuro-oncology.

Inclusion Criteria:

• Patients who underwent a brain PET/CT or PET/MRI scan with [18F]FET for clinical reasons during the study period.
• Age ≥ 18 years.
• Indication for the scan related to diagnosis, grading, assessment of treatment response or suspected recurrence of any brain tumour (primary or metastatic).
• Availability of the corresponding static and dynamic images.
• Signed informed consent.

Exclusion Criteria:

• . Pregnancy or breastfeeding