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The objective of this study is to assess the effect of repeated doses of itraconazole on the single dose pharmacokinetics (PK) of ABBV-722.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Period 1 & 2 | Experimental | In Period 1, participants will receive a single dose of ABBV-722. In Period 2, participants will receive multiple daily doses of Itraconazole and a single dose of ABBV-722. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ABBV-722 | Drug | Oral Tablet |
| |
| Itraconazole |
| Measure | Description | Time Frame |
|---|---|---|
| Maximum Observed Plasma Concentration (Cmax) of ABBV-722 | Cmax of ABBV-722 | Up to Day 8 in Period 1 and Up to Day 14 in Period 2 |
| Time to Cmax (Tmax) of ABBV-722 | Tmax of ABBV-722 | Up to Day 8 in Period 1 and Up to Day 14 in Period 2 |
| Area Under the Plasma Concentration-Time Curve From Time 0 to Time of Last Measurable Concentration (AUCt) of ABBV-722 | AUCt of ABBV-722 | Up to Day 8 in Period 1 and Up to Day 14 in Period 2 |
| Area Under the Plasma Concentration-Time Curve From Time 0 to Infinite Time (AUCinf) of ABBV-722 | AUCinf of ABBV-722 | Up to Day 8 in Period 1 and Up to Day 14 in Period 2 |
| Terminal Phase Elimination Rate Constant (β) of ABBV-722 | β of ABBV-722 | Up to Day 8 in Period 1 and Up to Day 14 in Period 2 |
| Terminal Phase Elimination Half-Life (t1/2) of ABBV-722 | t1/2 of ABBV-722 | Up to Day 8 in Period 1 and Up to Day 14 in Period 2 |
| Number of Participants with Adverse Events (AEs) | An AE is defined as any untoward medical occurrence in a patient or clinical investigation in which a participant is administered a pharmaceutical product which does not necessarily have a causal relationship with this treatment. | Up to Approximately 45 Days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| ABBVIE CALL CENTER | Contact | 844-663-3742 | abbvieclinicaltrials@abbvie.com |
| Name | Affiliation | Role |
|---|---|---|
| ABBVIE INC. | AbbVie | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Acpru /Id# 282143 | Recruiting | Grayslake | Illinois | 60030 | United States |
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| ID | Term |
|---|---|
| D017964 | Itraconazole |
| ID | Term |
|---|---|
| D014230 | Triazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Drug |
Oral Capsule |
|
| D010879 |
| Piperazines |