This single-center, single-blind, non-randomized crossover exploratory study evaluated the short-term effects of NatureU Burn on postprandial satiety in healthy adults. NatureU Burn is an oral dietary supplement containing Irvingia gabonensis seed extract and high-molecular-weight inulin. Fourteen healthy adults were enrolled, and 12 participants completed the study and were included in the effectiveness analysis. Each participant completed two test sessions separated by at least 48 hours: a reference food session with 75 g medical anhydrous glucose in 250 mL warm purified water and a test food session with one capsule of NatureU Burn plus 75 g glucose in 250 mL warm purified water. Satiety-related questionnaire scores were assessed at fasting baseline and at 30, 60, 90, 120, 180, and 240 minutes after the first bite in each session. The study assessed fullness, hunger, desire for food, and prospective food consumption, and monitored adverse reactions.

This exploratory clinical study was conducted to assess whether NatureU Burn, when consumed with a glucose reference food, was associated with changes in satiety-related subjective indicators compared with glucose alone. Eligible healthy adults completed screening, signed informed consent, and underwent two independent test sessions. For 2 days before each test, participants were instructed to maintain regular routines and a normal diet. On the day before testing, participants ate dinner between 18:00 and 20:00, avoided high-fiber and high-sugar foods, and fasted after 20:00. On the test morning, participants avoided strenuous exercise, sat quietly for 10 minutes before testing, and completed a fasting satiety scale before taking the assigned food. Participants consumed the assigned food and water within 5 to 10 minutes, and completed the satiety scale at 30, 60, 90, 120, 180, and 240 minutes after the first bite. The four evaluated satiety indicators were fullness, hunger, desire for food, and prospective food consumption. Food-affected changes were calculated relative to fasting baseline and compared between the NatureU Burn plus glucose session and the glucose reference session. Safety monitoring included adverse reactions throughout the testing process.

Inclusion Criteria:

• Healthy adults aged 18 to 50 years.
• Male or female participants.
• Body mass index within the normal range of 18.5 to 23.9 kg/m2.
• Regular habit of eating breakfast.
• Able to fast for at least 10 hours after dinner.
• Signed informed consent before enrollment.

Exclusion Criteria:

• Pregnant or breastfeeding women.
• Individuals engaged in heavy physical labor or high-intensity exercise.
• Chronic sleep deprivation during the previous 3 months.
• Self-reported body weight increase or decrease of at least 4 kg during the previous 3 months.
• Current use of weight-loss medications.
• Special dietary patterns, such as low-carbohydrate diet or intermittent fasting.
• Abnormal eating attitude based on eating attitude assessment.
• Serious cardiovascular, hepatic, renal, gastrointestinal, hematologic, or neurologic dysfunction.
• History of bariatric surgery.
• Major surgery or hospitalization within the previous 3 months.
• Eating disorders, including binge eating disorder, anorexia nervosa, or bulimia nervosa.
• Abnormal glucose metabolism or lipid metabolism.
• Intolerance or allergy to the test foods.
• Excessive smoking, defined as more than 15 cigarettes per day.
• Alcohol consumption greater than 15 g alcohol per day.

Individual participant data will not be shared due to privacy protection and ethical considerations.

The study was described as single-blind. Participants were masked. Investigator, care provider, and outcome assessor masking were not reported.