EFFECTS OF PROPOLIS AND ROYAL JELLY SUPPLEMENTATION ON INFLAMMATORY AND OXIDATIVE STRESS MARKERS IN PATIENTS WITH SYSTEMIC ARTERIAL HYPERTENSION

EFFECTS OF PROPOLIS AND ROYAL JELLY SUPPLEMENTATION ON INFLAMMATORY AND OXIDATIVE STRESS MARKERS IN PATIENTS WITH SYSTEMIC ARTERIAL HYPERTENSION

The study aims to evaluate the effect of the royal jelly and propolis on inflammation and oxidative stress in participants with systemic arterial hypertension. A longitudinal double-blind randomized clinical trial will be carried out, involving hypertensive participants for two months.

Royal jelly (RG) and propolis (P) are considered superfood that has been used in traditional medicine and dietary supplementation due to its antioxidant, anti-inflammatory, immunomodulatory, and regenerative properties. The antioxidant and anti-inflammatory effects of GR and P highlight their potential as a natural supplement for the prevention and management of several health conditions. Although in vitro and animal model data are promising, clinical studies are still needed to validate the effects of royal jelly and propolis in human populations.

Inclusion Criteria:

• Diagnosis of stage 1 and 2 hypertension
• Regular treatment for more than 6 months
• There have been no changes in medication doses over the last three months.

Exclusion Criteria:

• Autoimmune and infectious diseases, diabetes
• Chronic kidney disease, liver disease, cancer and AIDS
• Pregnant women
• Use of catabolic drugs or antibiotics
• Use of antioxidant vitamin supplements, prebiotics, probiotics, symbiotic
• Habitual intake of royal jelly and propolis