Vascular Endothelial Inflammation and Health Status In INOCA (VISION-INOCA)

A Single Center Diagnostic Study of Endothelial Inflammation and Health Status in Patients With Ischemia and Nonobstructive Coronary Arteries (INOCA)

The purpose of this study is to evaluate coronary artery and peripheral vein vascular endothelial profiles in patients with ischemia with non-obstructive coronary arteries (INOCA) who undergo coronary function testing (CFT). The aims are: (1) Evaluate coronary artery endothelial profiles and associations with coronary microvascular dysfunction (CMD) in INOCA. (2) Assess brachial vein endothelial cell profiles in patients with INOCA and associations with CMD, and (3) Characterize relationships between endothelial signatures and anginal symptoms, functional status, and physical activity at baseline and 1-year follow-up.

Inclusion Criteria:

1. Adult age ≥18 years referred for clinically indicated coronary angiography
2. Chronic coronary disease or potentially ischemic symptoms as the indication for coronary angiography
3. Possible or suspected ischemia with non-obstructive epicardial coronary arteries (INOCA)

Exclusion Criteria:

Clinical (Pre-Cath) Exclusion criteria:

1. Anemia (hemoglobin <9 mg/dl)
2. Severe valvular heart disease
3. Acute myocardial infarction within 30 days
4. Severe valvular heart disease
5. New York Heart Association (NYHA) Functional Class III or IV heart failure
6. Hypertrophic obstructive cardiomyopathy or severe left ventricular hypertrophy
7. Pregnancy (because of potential exercise/activity limitations and symptom changes)