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| Name | Class |
|---|---|
| East Tallinn Central Hospital | OTHER |
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The goal of this observational study is to identify the risk factors for post-thyroidectomy hypoparathyroidism in Estonia and to determine whether the magnesium level plays a significant role in the development of hypoparathyroidism. The main questions it aims to answer are:
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| Measure | Description | Time Frame |
|---|---|---|
| postoperative early hypoparathyroidism | Incidence of early post-thyroidectomy hypoparathyroidism, based on serum PTH levels measured on the morning of the first postoperative day | first postoperative day |
| Measure | Description | Time Frame |
|---|---|---|
| Risk factor assessment of post-thyroidectomy hypoparathyroidism | Risk factors will be categorized as patient-related, disease-related, and surgery-related variables. Risk factors will be assessed using multivariable logistic regression analysis, and results will be reported as odds ratios with 95% confidence intervals. Patient-related risk factors will be assessed using a structured study-specific questionnaire (including demographic and clinical history variables) and review of electronic medical records. Disease-related risk factors will be assessed using also preoperative laboratory measurements. Surgery-related risk factors will be assessed using standardized operative reports, including variables such as extent of thyroidectomy, identification and preservation of parathyroid glands, and intraoperative findings, recorded according to institutional surgical protocols. Patient- and disease-related variables will be assessed preoperatively, while surgery-related variables will be assessed intraoperatively. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients over the age of 18 at Tartu University Hospital and East Tallinn Central Hospital who are undergoing surgery involving both lobes of the thyroid gland (thyroidectomy, "near-total" thyroidectomy, subtotal thyroidectomy, and "completed" thyroidectomy), and who provide informed consent for this.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hanna Hollman, MD | Contact | +37259037517 | hanna.hollman@ut.ee |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| East Tallinn Central Hospital | Recruiting | Tallinn | Estonia |
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| ID | Term |
|---|---|
| D007011 | Hypoparathyroidism |
| ID | Term |
|---|---|
| D010279 | Parathyroid Diseases |
| D004700 | Endocrine System Diseases |
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| Preoperative and intraoperative periods |
| Serum magnesium levels as predictors of post-thyroidectomy hypoparathyroidism | Serum magnesium levels will be measured preoperatively (baseline, prior to surgery) and on postoperative day 1. The predictive value of preoperative and postoperative day 1 serum magnesium levels for early post-thyroidectomy hypoparathyroidism will be assessed using univariable and multivariable logistic regression analysis, with results reported as odds ratios and 95% confidence intervals. | Preoperative (baseline) and postoperative day 1; hypoparathyroidism assessed within 24 hours postoperatively |
| Postoperative permanent hypoparathyroidism | Incidence of permanent post-thyroidectomy hypoparathyroidism, defined as persistently low serum PTH levels and/or ongoing requirement for calcium and/or vitamin D supplementation at 12 months after surgery. | 12 months after surgery |
| Tartu University Hospital | Recruiting | Tartu | Estonia |
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