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This prospective observational study aims to evaluate whether sarcopenia and frailty affect the pharmacodynamic profile of rocuronium in geriatric patients undergoing elective surgery under general anesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group/Cohort 1-Frailty | Presence of frailty based on the Fried frailty phenotype. | ||
| Group/Cohort 2-Sarcopenia | Presence of sarcopenia based on preoperative clinical and ultrasonographic assessment. | ||
| Group/Cohort 3 - Frail and Sarcopenic Group | Geriatric patients who meet the criteria for both frailty and sarcopenia. | ||
| Group/Cohort 4 - Control Group | Geriatric patients who meet neither frailty nor sarcopenia criteria. |
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| Measure | Description | Time Frame |
|---|---|---|
| Rocuronium onset time | Time from intravenous administration of rocuronium to disappearance of all train-of-four responses, defined as train-of-four count 0, measured using quantitative neuromuscular monitoring | Perioperative/Periprocedural - during anesthesia induction |
| Measure | Description | Time Frame |
|---|---|---|
| Time from train-of-four count 0 to train-of-four count 2 | Time elapsed from achievement of train-of-four count 0 after the initial rocuronium dose to recovery of train-of-four count 2, recorded in minutes and measured using quantitative neuromuscular monitoring. | From achievement of train-of-four count 0 after the initial rocuronium dose until recovery of train-of-four count 2 during surgery |
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Inclusion Criteria:
Exclusion Criteria:
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The study population will consist of geriatric patients aged 65 years or older who are scheduled for elective surgery under general anesthesia with endotracheal intubation and rocuronium-induced neuromuscular blockade. Before surgery, patients will be evaluated for frailty and sarcopenia using predefined clinical and ultrasonographic criteria. According to these assessments, patients will be classified into four cohorts: frailty only, sarcopenia only, both frailty and sarcopenia, and neither frailty nor sarcopenia.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Betül kozanhan, M.D. | Contact | 05055044808 | betulkozanhan@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Betül Kozanhan, M.D. | SBÜ Konya EAH | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Betul Kozanhan | Recruiting | Konya | 42005 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| Time to train-of-four ratio 0.9 after sugammadex administration | Time from sugammadex administration to recovery of train-of-four ratio to 0.9, measured using quantitative neuromuscular monitoring. | From sugammadex administration until recovery of train-of-four ratio to 0.9 at the end of surgery |
| Total rocuronium dose | Total dose of rocuronium administered during anesthesia | From anesthesia induction until the end of surgery |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D010335 | Pathologic Processes |