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| ID | Type | Description | Link |
|---|---|---|---|
| 2026-A00010-51 | Other Identifier | ANSM |
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Currently, an interventional protocol for physical activity during pregnancy is underway at the Clermont University Hospital (PREGMOUV study). In addition, we have implemented a protocol for 2 years monitoring of children birthed of this study (NEOMOUV study).
Recent data from the scientific literature show that a woman's engagement in regular and appropriate physical activity during her pregnancy presents few dangers while ensuring benefits for the mother-baby dyad. Indeed, physical activity reduces maternal complications such as preeclampsia, gestational diabetes and depression and has many advantages for the child with in particular a reduction in the risk of macrosomia then obesity and diabetes.
Neonatal sepsis is a major risk factor for childhood mortality. There is strong negative association between cord blood levels of calprotectin and sepsis risk in human newborns with levels of calprotectin at birth are significantly lower in infants that later experience blood-culture-proven late-onset neonatal sepsis. In adults, plasma calprotectin levels increase following acute exercise. However after 4 weeks trainging plasma calprotectin level decrease. So in response to acute exercise, plasma calprotectin levels increase but in contrast, there is a negative association between basal plasma calprotectin levels and regular physical activity. Therefore, we do not know what impact mother' regular physical activity can have on the level of calprotectin in the cord blood.
The objective of this project is to investigate the impact of physical activity during pregnancy on calprotectin value at cord blood.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cord blood |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| physical activity level during pregnancy | Behavioral | Total physical activity time (in MET minutes/week) of pregnant women measured at Trimestry 3 (explanatory variable) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Calprotectin levels | Calprotectin levels (ng/mL), collected from cord blood immediately after birth according to Total physical activity time (in MET minutes/week) of pregnant women measured at Trimestry 3 | at birth |
| Measure | Description | Time Frame |
|---|---|---|
| calprotectin level | Calprotectin levels (ng/mL) in umbilical cord blood at birth according to delivery mode | at birth |
| calprotectin level | Calprotectin levels (ng/mL) in umbilical cord blood at birth according to maternal physical activity levels during pregnancy at T2 |
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Inclusion Criteria:
Exclusion Criteria:
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Newborns born to mothers who participated in the PregMouv study
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lise Laclautre | Contact | +334752963 | promo_interne_drci@chu-clermontferrand.fr |
| Name | Affiliation | Role |
|---|---|---|
| Solène FEL | University Hospital, Clermont-Ferrand | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Clermont-Ferrand | Recruiting | Clermont-Ferrand | 63000 | France |
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cord blood
| at birth |
| calprotectin level | Calprotectin levels (ng/mL) in umbilical cord blood at birth according to gestational age at birth | at birth |
| calprotectin level | Calprotectin levels (ng/mL) in umbilical cord blood at birth according to sedentary lifestyle levels at T2 and T3 | at birth |
| calprotectin level | Calprotectin levels (ng/mL) in umbilical cord blood at birth according to maternal body composition (kg/m²) | at birth |
| transcriptomic | mRNA expression level in umbilical cord blood at birth according to maternal body composition (kg/m²) | at birth |
| transciptomic | mRNA expression level in umbilical cord blood at birth according to delivery mode | at birth |
| transciptomic | mRNA expression level in umbilical cord blood at birth according to maternal physical activity levels during pregnancy at T2 | at birth |
| transciptomic | mRNA expression level in umbilical cord blood at birth according to gestational age at birth | at birth |
| transciptomic | mRNA expression level in umbilical cord blood at birth according to sedentary lifestyle levels at T2 and T3 | at birth |
| transciptomic | mRNA expression level in umbilical cord blood at birth according to maternal body composition (kg/m²) | at birth |