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| Name | Class |
|---|---|
| University of Pittsburgh Medical Center | OTHER |
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Electronic medical records dating back as far as available for each center to identify patients admitted to the hospital with a serum sodium ≤110 mmol/l. Data on patient demographics, presenting symptoms, vital signs, laboratory findings, treatment given, sodium correction rates, presence of risk factors for osmotic demyelination syndrome (ODS) and outcomes including suspected and MRI-confirmed ODS, in-hospital death, and imaging confirmation of cerebral edema
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with suspected or MRI-confirmed ODS | Patients without suspected or MRI-confirmed ODS |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hypertonic 3% saline | Drug | Rapid Correction of hyponatremia |
|
| Measure | Description | Time Frame |
|---|---|---|
| Osmotic demyelination syndrome | Neurological deterioration after treatment of hyponatremia | 1 to 14 days |
| MRI-confirmed Osmotic Demyelination Syndrome | Post treatment neurological deterioration with CPM and/or EPM | Within 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral edema | Cerebral edema documented by imaging or death or respiratory arrest from suspected cerebral edema | 2 days |
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Inclusion Criteria:
Exclusion Criteria:
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Patients age 18 or higher with serum sodium ≤110 mmol/L
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| Name | Affiliation | Role |
|---|---|---|
| Richard H Sterns, MD | University of Rochester | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Pittsburgh School of Medicine | Pittsburgh | Pennsylvania | 15213 | United States |
Serum sodium values, outcomes and correction rates
June 30 2026 to June 30 2034
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| ID | Term |
|---|---|
| D001929 | Brain Edema |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| D003894 | Deamino Arginine Vasopressin |
| D005947 | Glucose |
| D014867 | Water |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |
| D001127 | Arginine Vasopressin |
| D014667 | Vasopressins |
| D010909 | Pituitary Hormones, Posterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D009479 | Neuropeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009842 | Oligopeptides |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |
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