Suzetrigine vs Norco-postoperative Mohs Pain

Non-Opioid Pain Management After Mohs Reconstruction: An Investigator-Initiated, Prospective, Randomized Clinical Trial of Suzetrigine vs Hydrocodone/Acetaminophen

To compare suzetrigine versus hydrocodone/acetaminophen for postoperative pain control following dermatologic surgery.

This study is a randomized, controlled trial that is evaluating the safety and efficacy of suzetrigine as a postoperative pain medication compared to the standard of care Hydrocodone/Acetaminophen in patients undergoing Mohs micrographic surgery (MMS) who are at high-risk for postoperative pain and opioid use. The goal is to reduce opioid prescription use and give patients a non-opioid pain medication option for particularly painful surgeries. Patients will be randomized into one of two groups, one group will receive the interventional medication and the other the standard of care medication.

Inclusion Criteria:

• adults between the age of 18-89
• individuals who have a cutaneous tumor treated by MMS

Exclusion Criteria:

• individuals younger than 18 and older than 89
• individuals taking medications that interact with the CYP3A (Cytochrome P450 3A) pathway
• individuals with liver disease