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The aim of this study is to compare between nebulized dexmedetomidine, ketamine, or midazolam for premedication in children undergoing adenotonsillectomy.
The aim of this study is to compare between nebulized dexmedetomidine, ketamine, or midazolam for premedication in children undergoing adenotonsillectomy.
Primary outcome:
• A five-point sedation score on arrival in the operating room 30 min after drug administration.
Secondary outcomes:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group K :nebulized ketamine group | Experimental | Group K: Patients will receive nebulized ketamine 2 mg kg -1 |
|
| Group D: dexmedetomidine group | Experimental | Group D: Patients will receive dexmedetomidine 2 mcg kg -1 |
|
| Group M:midazolam group | Experimental | (Group M): Patients will receive midazolam 0.2 mg kg -1 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Group K:nebulized ketamine group | Drug | Patients will receive nebulized ketamine 2 mg kg -1 |
|
| Measure | Description | Time Frame |
|---|---|---|
| A five-point sedation score on arrival in the operating room | Sedation level will be assessed at the same time points mentioned above using a five-point sedation scale score as follows: 1= agitated, 2= alert, 3= calm, 4= drowsy, and 5=asleep . A score ≥ 3 will be considered as acceptable sedation. | 30 min after drug administration |
| Measure | Description | Time Frame |
|---|---|---|
| Parental separation anxiety scale | parental separation will be assessed by a four-point parental separation anxiety scale (PSAS) as follows: 1= easy separation, 2= whimpers, but is easily reassured, not clinging, 3= cries and cannot be easily reassured, but not clinging to parents, and 4= crying and clinging to parents. PSAS scores of 1 and 2 signified acceptable separation whereas scores of 3 and 4 will be classified as difficult separation . |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tanta University | Tanta | Egypt |
It will be available when it needed
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| Group D:dexmedetomidine group | Drug | Patients will receive dexmedetomidine 2 mcg kg -1 |
|
| Group M: midazolam group | Drug | Patients will receive midazolam 0.2 mg kg -1 |
|
| 2 hours |