Local literature is deprived of data comparing the effectiveness of esomeprazole and vonoprazan in patients with gastroesophageal reflux disease (GERD). This study was planned with the objective of comparing the effectiveness of esomeprazole versus vonoprazan in patients diagnosed with GERD.

Addressing the pressing need for an in-depth understanding and comparison of treatment options for the escalating prevalence of GERD, a condition significantly impacting patients' quality of life, is crucial. The study's results would not only provide local data, but also help doctors choose between esomeprazole and vonoprazan as the best treatment option. This would improve patient care and help doctors make better decisions, which would ultimately lead to better management of GERD and the overall health of patients.

Inclusion Criteria:

• Any gender
• Aged 18 to 65 years
• Presenting with GERD

Exclusion Criteria:

• Patients with hepatic, renal, respiratory, or cardiac disease accessed on history and medical records.
• Any previous history of malignancy accessed from medical records.
• Pregnancy and Lactation
• Currently using histamine-2 receptor antagonists, antacids, gastrointestinal motility stimulants, and steroids.
• History of drug allergy to proton pump Inhibitors (PPIs).

Data can be shared on a reasonable request.