Possible Augmentation Of NB-UVB Induced Pigmentation In NSV By Carboxy.

Evaluation Of Carboxytherapy As An Adjuvant To Narrowband-Ultraviolet B Phototherapy For The Treatment Of Stable Non-Segmental Vitiligo: A Clinical And Biochemical Study .

Patients with stable vitiligo with 2 or more symmetric patches, 2 on acral sites and/or 2 on non acral sites will be recruited and assessed for eligibility for inclusion to receive NB-UVB on the whole body, and carboxytherapy on one randomized side.

Inclusion Criteria:

• Subjects with stable non-segmental vitiligo (≥2 symmetrical patches of diameter less than 2 cm on acral or ≥ 2 symmetrical patches on non-acral sites). Subjects were stable for twelve or more months.

Exclusion Criteria:

• Subjects with unstable vitiligo.

  • Subjects with segmental vitiligo.
  • Pregnant females.
  • Severe anemia (Hb <7 gm/dl).
  • Cardiac/hepatic/renal/respiratory failure.
  • Superficial thrombophlebitis.
  • Subjects with history of skin malignancy or precancerous conditions like Xeroderma pigmentosum.
  • Subjects with other autoimmune disorders.
  • Systemic drugs for vitiligo in the last 3 months.