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Laryngeal Mask Airways Are Supraglottic Devices Used to Maintain Airway Patency During Anesthesia and in Difficult Airways. LMA may help in reducing postoperative pulmonary complications. IV Dexmedetomidine Improves LMA Insertion Success and Decreases trials number, While IV Lidocaine Decreases Postoperative Cough. This is a randomized interventional trial comparing both drugs. IV DEX will be compared vs IV lidocaine regarding the feasibility of insertion, number of trials, incidence of cough, postoperative pulmonary complications and hemodynamic profile.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group (D) DEX | Active Comparator | Dose: 0.2 mcg/kg IV in 10 mL saline, infused over 10 min pre-induction. |
|
| Group (L) Lidocaine | Active Comparator | Dose: 1.5 mg/kg IV (max 100 mg) in 10 ml saline over 1 min before induction. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexamedomedine | Drug | IV 0.2 mic/ kg of dexmedetomidine will be diluted over 10 ml saline and given to the patient over 10 minutes before induction and assess the feasibility of classic LMA insertion |
| Measure | Description | Time Frame |
|---|---|---|
| First-attempt insertion success rate | The success of the first trial of classic LMA insertion will be assessed. Binary: yes or no. | After induction of anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| Ease of insertion (4-point scale) | Grade 1: No resistance. Grade 2: Mild resistance. Grade 3: Moderate resistance. Grade 4: Failed insertion and need for another airway management tool. | After Induction of anesthesia |
| Heart rate |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Abdelrahman Hamdy, Lecturer | Contact | +201060989574 | abdelrahmanhm89@gmail.com | |
| Mohammed Adel, Lecturer | Contact | 01050727722 | +2 |
| Name | Affiliation | Role |
|---|---|---|
| Abdelrahman Hamdy | Asyut University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine Assiut University | Asyut | Asyut Governorate | 71621 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30878762 | Background | Li L, Zhang Z, Yao Z, Wang H, Wang H, An H, Yao J. The impact of laryngeal mask versus other airways on perioperative respiratory adverse events in children: A systematic review and meta-analysis of randomized controlled trials. Int J Surg. 2019 Apr;64:40-48. doi: 10.1016/j.ijsu.2019.02.020. Epub 2019 Mar 13. | |
| 35016404 | Background |
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2027 after publishing the study and for 1 year after
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|
| Lidocaine (drug) | Drug | IV 1.5 mg/kg of lidocaine will be diluted over 10 ml saline and given to the patient 1 minute before induction and assess the feasibility of classic LMA insertion |
|
Monitored continuously and recorded every 15 minutes. Atropine IV will be given if bradycardia occurs.
| Every 15 minutes till recovery |
| MAP | Mean arterial blood pressure | Every 15 minutes |
| Recovery Time | Time from discontinuation of anesthesia till the child is fully awake. | After cessation of anesthesia administration |
| Postoperative Agitation | PAED scale
| In PACU |
| Postoperative Complications | Laryngeal Spasm, Coughing | 0,1,2,6 hours postoperative. |
| PONV | PONV grade Patient response 0 Without PONV I Nausea without vomiting II Nausea with vomiting (< 3 times/d) III Vomiting ≥ 3 times/d | 24 hours postoperative |
| Postoperative sore throat (0-3 scale). | 0 (none)
| 24 hours postoperative |
| Ju Q, Xiao Z, Sun W, Zhu M, Lv P. The anesthesia induction effect of dexmedetomidine in patients undergoing laryngeal mask intubation: a systematic review and meta-analysis of 7 RCTs. Ann Palliat Med. 2021 Dec;10(12):12358-12366. doi: 10.21037/apm-21-2971. |
| 26473098 | Background | Gharaei B, Jafari A, Poor Zamany M, Kamranmanesh M, Aghamohammadi H, Roodneshin F, Teymourian H, Khazaie Y, Dadkhah P. Topical Versus Intravenous Lidocaine in Children With Upper Respiratory Infection Undergoing Anesthesia: A Randomized, Double Blind, Clinical Trial. Anesth Pain Med. 2015 Aug 22;5(4):e23501. doi: 10.5812/aapm.23501v2. eCollection 2015 Aug. |
| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D008012 | Lidocaine |
| D004364 | Pharmaceutical Preparations |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
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