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A study investigating the effects of non-invasive electrical stimulation of deep brain structures on working memory, attention, and executive functions involved in everyday activities. Currently, there is no effective treatment for impairments in these functions. The study will evaluate the effects of non-invasive electrical stimulation in both healthy older adults and individuals with mild impairment of these functions.
The study combines magnetic resonance imaging (MRI) with non-invasive brain stimulation targeting deep brain structures. Its aim is to improve understanding of the neural mechanisms underlying these cognitive functions and their impairments, as well as to explore the mechanisms of non-invasive brain stimulation for potential future therapeutic applications.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 20 Hz striatal stimulation | Experimental | Striatum will be targeted by using two pairs of high-frequency tES with a low-frequency offset (20 Hz), creating an interference hotspot targeting the deep brain structure (deep-tES). |
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| 60 Hz striatal stimulation | Experimental | Striatum will be targeted by using two pairs of high-frequency tES with a low-frequency offset (60 Hz), creating an interference hotspot targeting the deep brain structure (deep-tES). |
|
| Sham striatal stimulation | Sham Comparator | Striatum will be targeted by using two pairs of high-frequency tES with no low-frequency offset. The stimulation will be applied only shortly and turned off after ramp-up and ramp-down period. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (20 Hz) | Other | Striatum will be targeted by using at least two pairs of high-frequency tES with a low-frequency (20 Hz) offset, creating an interference hotspot targeting the deep brain structure (deep-tES). |
| Measure | Description | Time Frame |
|---|---|---|
| The neural underpinning of NIBS-induced changes quantified by task-fMRI activations | During intervention ( approximately 10 minutes) | |
| The neural underpinning of NIBS-induced changes quantified by network-based analytical approaches. | During intervention ( approximately 10 minutes) |
| Measure | Description | Time Frame |
|---|---|---|
| Working memory performance - Reaction times | Reaction times of an N-back task between the real and sham stimulation condition in a cross-over design. | During intervention (approx 10 minutes) |
| Working memory parformance - Accuracy |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Monika Pupíková | Contact | +420549498818 | monika.pupikova@ceitec.muni.cz |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CEITEC Masaryk University | Recruiting | Brno | 612 00 | Czechia |
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| Control striatal stimulation | Other | A high-frequency tES without low-frequency offset. It will consist of two oscillatory high-frequency currents without any frequency shifts, which induces similar skin sensations as deep-tES and will be applied just for a ramp-up/ramp-down phases at the beginning of the stimulation and afterwards will be switched off. |
|
| Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (60 Hz) | Other | Striatum will be targeted by using at least two pairs of high-frequency tES with a low-frequency (60 Hz) offset, creating an interference hotspot targeting the deep brain structure (deep-tES). |
|
Accuracy (measured as D-prime) of an N-back task between the real and sham stimulation condition in a cross-over design.
| During intervention ( approximately 10 minutes) |
| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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