Oral Propranolol Versus Fractional Carbon Dioxide CO2 Laser Assisted Delivery of Topical Timolol for Treatment of Infantile Hemangioma

Oral Propranolol Versus Fractional Carbon Dioxide CO2 Laser Assisted Delivery of Topical Timolol for Treatment of Infantile Hemangioma; A Randomized Controlled Comparative Study

To assess and compare the efficacy of systemic beta-blocker therapy with the efficacy and safety of fractional carbon dioxide laser-assisted delivery of a topical beta-blocker solution in the treatment of infantile hemangioma.

Inclusion Criteria:

, aged 1 month to 12 years

- presenting with superficial, deep, mixed, or proliferating IH.

Exclusion Criteria:

• other cutaneous or systemic infections
• chronic systemic diseases
• known allergy to topical timolol maleate
• contraindications to laser or beta-blocker therapy
• IH involving mucosal or perimucosal sites
• and a history of adverse reactions to laser therapy or keloid tendency.