Palatable Elemental Diet for Gastrointestinal Symptoms in Chronic Pancreatitis

Feasibility of a Novel Oral Palatable Elemental Diet for Gastrointestinal Symptoms in Chronic Pancreatitis

The goal of this clinical trial is to learn whether a 2-week exclusive palatable elemental diet is feasible, tolerable, and acceptable for adults with chronic pancreatitis and bothersome gastrointestinal symptoms. An elemental diet is a nutritionally complete formula made from ingredients that are easy to absorb. The main questions it aims to answer are whether participants can complete the diet as planned, and whether they can take in most of the prescribed formula, and how acceptable the study diet is to participants at the end of the 2-week diet period.

Inclusion Criteria:

• Adults aged 18 to 75 years
• Clinical diagnosis of chronic pancreatitis based on medical history and study physician assessment
• Self-reported chronic pancreatitis-related gastrointestinal symptoms within 30 days before enrollment, with significant global gastrointestinal symptom burden defined as a Structured Assessment of Gastrointestinal Symptoms (SAGIS) score of 16 or higher

Exclusion Criteria:

• Pancreatic tumor or pancreatic cancer
• History of pancreatic surgery
• Pregnancy or breastfeeding
• Diagnosis of a condition other than chronic pancreatitis that contributes to gastrointestinal symptoms, based on medical history or study physician assessment
• Active infection or antibiotic use within the last month
• History of phenylketonuria
• Insulin-dependent diabetes or diabetes requiring insulin treatment